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CAPN9 — NFKBIA
Text-mined interactions from Literome
Shumway et al., J Biol Chem 1999
:
Moreover, the muCaMLD of calpain acts as a competitive inhibitor of
calpain dependent
IkappaBalpha degradation
Pianetti et al., Oncogene 2001
(Breast Neoplasms...) :
Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving
calpain mediated degradation of
IkappaB-alpha that can be inhibited by the tumor suppressor PTEN ... Inhibitors of
calpain , but not the proteasome,
blocked IkappaB-alpha degradation
Shen et al., J Immunol 2001
:
Phosphorylation by the protein kinase CK2 promotes
calpain mediated degradation of
IkappaBalpha ... CK2 phosphorylation enhanced
mu-calpain mediated degradation of wild-type
IkappaBalpha , but not of mutant 3CIkappaBalpha, with S283A, T291A, and T299A mutations in phosphorylation sites within the PEST domain ... These findings demonstrate for the first time that CK2 phosphorylation of serine/threonine residues in the PEST domain promotes
calpain mediated degradation of
IkappaBalpha and thereby increases basal NF-kappaB levels in IgM ( + ) B cells
Schölzke et al., Eur J Neurosci 2003
:
However, inhibition of the glutamate activated Ca2+ dependent protease
calpain by calpeptin completely
blocked IkappaBalpha degradation and reduced the nuclear translocation of p65
Schaecher et al., Neurochem Res 2004
:
Furthermore,
calpain inhibition
increased IkB alpha levels compared to nonactivated controls ... The results suggest that
calpain plays an important role in
IkB alpha degradation, a crucial event in T cell activation
Ponnappan et al., Immunity & ageing : I & A 2005
:
Constitutive degradation of
IkappaBalpha in human T lymphocytes is
mediated by
calpain
Młynarczuk-Biały et al., Cancer Res 2006
(Melanoma) :
Here, we show that cisplatin resistance in MeWo ( cis1 ) is accompanied by a change in the NF-kappaB activation pathway in favor of
calpain mediated
IkappaBalpha degradation
Cheng et al., Arch Biochem Biophys 2008
:
To explore this potential anti-apoptotic mechanism, we inhibited calpain and proteasome activity in oridonin induced L929 cell apoptosis, and discovered that the inducible
IkappaBalpha proteolysis was partially
blocked by the inhibition of either
calpain or proteasome, but completely blocked by the inhibition of both
Chae et al., Blood 2008
(Familial Mediterranean Fever) :
The interaction of N-terminal pyrin with IkappaB-alpha induced
calpain mediated degradation of
IkappaB-alpha , thus potentiating NF-kappaB activation
Hamelet et al., Mol Genet Metab 2009
(Fatty Liver...) :
Our results suggest that hyperhomocysteinemia induces
calpain mediated
I kappaB alpha degradation which is responsible for anti-apoptotic signals in liver
Wei et al., Am J Physiol Cell Physiol 2009
:
Instead,
calpain inhibitor can
block the
IkappaBalpha degradation induced by particles
Li et al., J Biol Chem 2010
(Multiple Myeloma) :
Proteasome inhibitor PS-341 ( bortezomib ) induces
calpain dependent
IkappaB(alpha) degradation ... These data together indicate that PS-341 induces a
calpain mediated
IkappaB(alpha) degradation independent of caspases
Kim et al., Biochem Biophys Res Commun 2010
(Neoplasms) :
Interestingly, the combined inhibition of
calpain and the proteasome
resulted in an increased accumulation of both I-kappaBalpha polymers and
I-kappaBalpha , concurrent with an inhibition of NF-kappaB activity in MDA-MB-231 cells
Chen et al., Arch Biochem Biophys 1997
:
This suggests that
calpain contributes to silica induced I kappa B alpha degradation and NF-kappa B activation but not to LPS induced
I kappa B alpha degradation and NF-kappa B activation