UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to PIK3CA

PIK3CA — STAT5B

Pathways - manually collected, often from reviews:

NCI Pathway Database IL2 signaling events mediated by STAT5: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → STAT5 (dimer)-active (STAT5B/STAT5A) (transcription, activates)
Moriggl et al., Immunity 1999, Brennan et al., Immunity 1997
Evidence: mutant phenotype, other species