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CALM1 — PLN
Text-mined interactions from Literome
Gao et al., Biochim Biophys Acta 1992
:
This interaction, relevant to the mechanism of
calmodulin dependent phosphorylation of
phospholamban that relieves its inhibitory influence on the calcium pump, provides a useful model system for comparative study of the properties of calmodulin binding domains
James et al., Nature 1989
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The calcium pump is activated by cyclic AMP- and
calmodulin dependent phosphorylation of
phospholamban , an integral membrane protein of the sarcoplasmic reticulum
Karczewski et al., Biomed Biochim Acta 1986
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Indirect technique for the estimation of cAMP dependent and
Ca2+/calmodulin dependent
phospholamban phosphorylation state in canine heart in vivo ... This method allows the separate detection of cAMP dependent and
Ca2+/calmodulin dependent
phospholamban phosphorylation
Lindemann et al., J Biol Chem 1985
:
This study was conducted to determine if
Ca2+-calmodulin dependent phosphorylation of
phospholamban occurs in response to physiologic increases in intracellular Ca2+ in intact myocardium ...
Ca2+-calmodulin dependent phosphorylation of
phospholamban may occur in response to agents which stimulate cAMP dependent mechanisms in intact myocardium
Will et al., Experientia 1985
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Phylogenetic changes are indicated by marked differences among species in cardiac phospholamban content and by the absence of
Ca2+/calmodulin dependent
phospholamban phosphorylation at an early developmental stage
Davis et al., J Biol Chem 1983
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These results were found to be specific for
calcium-calmodulin dependent phosphorylation of
phospholamban
Tada et al., J Mol Cell Cardiol 1983
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To elucidate the role of 22000-dalton protein phospholamban, a putative regulator of Ca2+ dependent ATPase of cardiac sarcoplasmic reticulum, we examined the relationship between cyclic AMP- and
calmodulin dependent phosphorylation of
phospholamban and their effects on ATPase activity and calcium transport of cardiac sarcoplasmic reticulum ... Cyclic AMP dependent phosphorylation of phospholamban was independent of Ca2+, whereas
calmodulin dependent phosphorylation of
phospholamban was dependent on Ca2+ within a range between 0.2 and 50 microM ... Cyclic AMP- and
calmodulin dependent phosphorylation of
phospholamban occurred independently ; when both kinases were operative, the amounts of phosphorylation were additive ... The ATPase activity was stimulated by either cyclic AMP- or
calmodulin dependent phosphorylation of
phospholamban at Ca2+ concentrations up to 2 microM ... Calcium uptake was similarly augmented by cyclic AMP- and/or
calmodulin dependent phosphorylation of
phospholamban
Cavadore et al., Biochimie 1981
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Beside a direct trigger of sarcomeric muscle contraction through binding of troponin C, calcium ions trigger or modulate contractility through calcium-calmodulin dependent myosin light chain kinases, and increase the rate of relaxation through the
calmodulin dependent phosphorylation of
phospholamban , the activator of the cardiac sarcoplasmic reticulum calcium pump
Strasburg et al., Biochim Biophys Acta 1993
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However, similar concentrations of chymotrypsin resulted in a loss of both calmodulin affinity labeling and
calmodulin dependent phosphorylation of
phospholamban ( at Thr-17 ) ... These data suggest that binding of calmodulin to phospholamban may be an essential intermediate step in the
calmodulin dependent phosphorylation of
phospholamban
Odermatt et al., J Biol Chem 1996
:
The vmax of the Ca2+-ATPase of cardiac sarcoplasmic reticulum ( SERCA2a ) is not altered by
Ca2+/calmodulin dependent phosphorylation or by interaction with
phospholamban