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IL1A — LEO1

Text-mined interactions from Literome

Warren et al., Am J Pathol 1992 (Acute Disease...) : Stimulation of isolated mouse alveolar macrophages with recombinant murine IL-1 beta or IL-1 alpha resulted in rapid, dose dependent, and cell concentration dependent increases in PAF secretion
Mizoguchi et al., J Gastroenterol Hepatol 1991 : These results indicated that PAF produced by hepatic sinusoidal endothelial cells is affected by IL-1 and arachidonic acid metabolites, suggesting that immune and inflammatory reactions in these cells may be regulated by chemical mediators produced by the cells themselves
Barthelson et al., J Allergy Clin Immunol 1990 : The effects of PAF on IL-1 release by human monocytes were studied with PAF alone and in combination with interferon-gamma ... These studies confirmed that PAF stimulates IL-1 release at two different ranges of PAF concentrations, 100 fM to 1 pM and 100 pM to 1 nM ... PAF effects on IL-1 release were specific to the form of PAF that is biologically active in most system ; ( S ) -PAF and lyso-PAF had no effect
Bussolino et al., J Lipid Mediat 1990 : We compared the effect of purified recombinant human TNF alpha, TNF beta and IL-1 on the production of platelet activating factor (PAF) in HEC
Rola-Pleszczynski et al., J Lipid Mediat 1990 : We have recently shown that platelet activating factor (PAF) can markedly enhance the production of tumor necrosis factor (TNF) and interleukin-1 (IL-1) by human monocytes stimulated with lipopolysaccharide or muramyl dipeptide ( MDP )
Pignol et al., J Lipid Mediat 1990 : In contrast, no effect of PAF on IL-1/ETAF release was observed
Pignol et al., J Lipid Mediat 1990 : The pharmacologic modulation of the effect of platelet activating factor (PAF) on the interleukin-1 (IL-1) activity present in the supernatants from lipopolysaccharide (LPS) stimulated macrophages was investigated ... Association of PT with PAF suppressed the enhancing effect of 10 fM PAF on the IL-1 activity present in the supernatants from LPS stimulated macrophages ... Thus, the enhancing effect of PAF on IL-1 release appears to be due to the production of lipoxygenase metabolites, leading to superoxide production and alterations of cAMP levels
Barthelson et al., Cell Immunol 1990 : The THP-1 human monocytic leukemia cell line, was used to study the mechanism by which PAF stimulates IL-1 release
Vlachogianni et al., Cytokine 2013 : IL-1ß increased lyso-PAF acetyltrasnferase activity which was peaked at 3h and kept elevated till 12h ... Finally, a transient stimulation of intracellular PAF-AH was induced by IL-1ß at 3h while incubation of U-937 with the PAF acetylhydrolase inhibitor pefabloc in the presence or absence of IL-1ß led to a strong sustained increase of intracellular PAF levels
Pignol et al., Int Arch Allergy Appl Immunol 1989 : The decrease in IL-1 synthesis induced by 28 micrograms PAF and the increase in IL-2 production evoked by 1 microgram PAF were not observed in rats treated daily with the PAF antagonist, BN 52021
Bussolino et al., J Clin Invest 1986 : To study the mechanism of IL-1 induced HEC-PAF production we tested the activity of 1-O-alkyl-sn-glycero-3-phosphocholine : acetyl/coenzyme A acetyltransferase in HEC ... The regulation of PAF generation in HEC by IL-1 may be an important aspect of the two-way interaction between immunocompetent cells and vascular tissue
Camussi et al., J Exp Med 1988 : TNF and IL-1 stimulate the synthesis and release of platelet activating factor (PAF) by neutrophils and vascular endothelial cells
Bussolino et al., J Biol Chem 1988 : About 30 % of PAF produced in response to either TNF or IL-1 is released into the medium, whereas approximately 70 % remains cell associated ... This suggests that PAF is synthesized by the same pathway in response to TNF or IL-1
Breviario et al., J Immunol 1988 : Overall these results indicate that IL-1 induced PAF production by EC does not significantly contribute to PMN adhesion to them
Pignol et al., Prostaglandins 1987 : PAF-acether , at doses ranging from 1pM to 0.1 microM did not induce a significative release and/or synthesis of IL1 from monocytes
Bussolino et al., Pharmacol Res Commun 1986 : Monocyte derived interleukin 1 (IL 1) induced the platelet activating factor (PAF) production in cultured human endothelial cells ( HEC )
Dejana et al., Blood 1987 : PAF synthesis was stimulated by murine and human recombinant IL 1 alpha but not by human recombinant IL 1 beta and 22K factor
Bussolino et al., Eur J Immunol 1994 : The generation of this elastase-like protein seems to be important for the synthesis of PAF induced by TNF-alpha and IL-1 alpha , as suggested by the following observations : ( a ) it precedes the synthesis of PAF ; ( b ) the inhibitors of serine protease and anti-human elastase antibody prevent the synthesis of PAF and the activation of 1-O-alkyl-2-lyso-glycerophosphocholine acetyl-CoA : acetyltransferase, which is a key enzyme of the PAF remodelling pathway ; ( c ) elastase, at concentrations similar to that detectable in the medium of cytokine activated EC, elicits a rapid synthesis of PAF by EC
Vogels et al., Infect Immun 1994 (Gram-Negative Bacterial Infections...) : Since IL-1 induces production of tumor necrosis factor alpha (TNF-alpha), granulocyte-macrophage colony stimulating factor ( GM-CSF ), platelet activating factor (PAF) , and arachidonic acid metabolites, we investigated the potential role of these substances in IL-1 induced protection
Hashimoto et al., Acta Med Okayama 1993 : These results suggest that central IL-1 stimulates both the HPA axis and the sympathetic-adrenomedullary system, that a higher dose of IL-1 stimulates a mechanism to antagonize the elevation of blood pressure and heart rate and that central PAF is not involved in the control of the sympathetic-adrenomedullary system
Im et al., Cancer Res 1996 (Lung Neoplasms...) : The effect of platelet activating factor (PAF) on experimental pulmonary metastasis by the B16F10 murine melanoma and the possible involvement of PAF in the activities of tumor necrosis factor alpha (TNF-alpha) and interleukin 1alpha (IL-1alpha) in tumor metastasis were investigated
Dupuis et al., Res Immunol 1997 : By contrast, M-CSF ( 1000 U/ml ), GM-CSF ( 100 ng/ml ), IL1 , IL3, IL6 and stem cell factor ( 10 ng/ml ) did not stimulate PAF production