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MMP3 — NFKB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Mengshol et al., Arthritis Rheum 2000
(MAP Kinase Signaling System) :
In chondrosarcoma cells,
MMP-1 induction depends on p38 and MEK ( an MAPK kinase of the extracellular signal regulated kinase pathway ) and does not
require JNK or
NF-kappaB
Shukla et al., Neoplasia (New York, N.Y.) 2004
(Adenocarcinoma...) :
The nuclear levels of NF-kappaB/p65 correlated with concurrent increase in cytosolic levels of IkappaBalpha along with
NF-kappaB dependent expression of Bcl2, cyclin D1,
MMP-9 , and VEGF
Dai et al., Ann Rheum Dis 2005
(Arthritis...) :
In chondrocytes responding to IL18, IL18 ( 1-100 ng/ml ) slightly increased the production of MMP-1,
MMP-3 , and MMP-13, which was
blocked by
NF-kappaB inhibitor and p38 mitogen activated protein kinase inhibitor ... In chondrocytes responding to IL18, IL18 ( 1-100 ng/ml ) slightly increased the production of MMP-1,
MMP-3 , and MMP-13, which was
blocked by
NF-kappaB inhibitor and p38 mitogen activated protein kinase inhibitor
Yoshida et al., Respirology 2006
(Pulmonary Emphysema) :
A specific inhibitor of
NF-kappaB reduced
MMP production by alveolar macrophages from SP-D-/- mice
Fan et al., Rheumatol Int 2006
:
Role of mitogen activated protein kinases and
NFkappaB on IL-1beta induced effects on collagen type II,
MMP-1 and 13 mRNA expression in normal articular human chondrocytes
Bachmeier et al., Cell Physiol Biochem 2007
(Breast Neoplasms...) :
68 % of Curcumin treated but only 17 % of untreated animals showed no or very few lung metastases, most likely as a consequence of down-regulation of
NFkappa B/AP-1 dependent
MMP expression and direct apoptotic effects on circulating tumor cells but not on established metastases
Bogatkevich et al., Arthritis Rheum 2007
(MAP Kinase Signaling System...) :
Inhibition of
MMP activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not
prevent HGF induced ERK-1/2 phosphorylation and
NF-kappaB activity, but significantly restored HGF inhibited collagen and CTGF accumulation
Lin et al., Rheumatol Int 2008
(Chondrosarcoma...) :
Using chondrosarcoma cells stimulated with IL-1beta, the effects of GLN on the mRNA and protein levels of
MMP-3 , the
activation of JNK, ERK, p38,
NF-kappaB , and AP-1, the nuclear translocation of NF-kappaB/Rel family members, and PI3-kinase/Akt activation were studied
Woo et al., J Neurochem 2008
:
Inhibition of
MMP-3 or -9 significantly
suppressed the expression of iNOS and pro-inflammatory cytokines and the activities of
NF-kappaB , AP-1, and MAPK in LPS stimulated microglia
Meng et al., Toxicol Lett 2009
:
Mechanistic studies indicate that B [ a ] P-induced transcriptional activation of
MMP-3 is not
mediated by AP-1,
NF-kappaB
Castier et al., Antioxid Redox Signal 2009
:
Hence, induction of
NF-kappaB by shear stress
contributes to
MMP induction and allows long-term flow induced vascular enlargement
Moon et al., Int Immunopharmacol 2010
(Arthritis, Experimental...) :
Additionally, by altering
nuclear factor (NF)-kappaB transcription activity in FLSs, curcumin
inhibited PGE ( 2 ) production, COX-2 expression, and
MMP secretion
Martinez-Orozco et al., Eur J Cell Biol 2010
(Neoplasm Invasiveness) :
We demonstrate here that AA promotes an increase in vimentin and N-cadherin expression,
MMP-9 secretion, a decrease in E-cadherin junctional levels, and the
activation of FAK, Src and
NF-kappaB in MCF10A cells
Souslova et al., PloS one 2010
(Atherosclerosis) :
Allele-specific
regulation of
matrix metalloproteinase-3 gene by transcription factor
NFkappaB
Green et al., J Immunol 2010
(Tuberculosis, Central Nervous System) :
Chemical inhibition and promoter-reporter analyses showed that
NF-kappaB and AP-1 c-Jun/FosB heterodimers
regulate CoMTb induced
MMP-1/-3 secretion
Lee et al., J Immunol 2010
:
Inhibition of
MMP-3 or -9 also
suppressed the activities of MAPK,
NF-kappaB , and AP-1
Suzuki et al., J Pharmacol Sci 2010
(Brain Ischemia...) :
MMP-3 was upregulated by t-PA in endothelial cells, but the upregulation was
prevented by the inhibition of either low-density lipoprotein receptor related protein ( LRP ) or
nuclear factor kappa-B (NF-kappaB) activation