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AKT1 — SERPINE1

Text-mined interactions from Literome

Kietzmann et al., Blood 2003 (Anoxia) : Overexpression of a constitutively active PKB led to induction of PAI-1 mRNA expression and of luciferase ( Luc ) activity from a gene construct containing 766 bp of the rat PAI-1 promoter ... Mutation of the hypoxia response elements ( HRE-1 and HRE-2 ) in rat PAI-1 promoter, which could bind hypoxia inducible factor-1 (HIF-1), abolished the induction of PAI-1 by insulin and PKB
Kietzmann et al., Thromb Haemost 2003 (Anoxia...) : However, the role of MAPKs and PKB in HIF-1 mediated PAI-1 regulation is not clear ... Consistently, overexpression of PKB or of the p38 upstream kinases MKK6 and MKK3 and of JNK, but not of ERK, enhanced PAI-1 mRNA levels