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BCL2 — PPP2R1A
Text-mined interactions from Literome
Lin et al., J Biol Chem 2006
:
PP2A regulates
BCL-2 phosphorylation and proteasome mediated degradation at the endoplasmic reticulum ... Knock down or pharmacological inhibition of
PP2A caused degradation of phosphorylated
BCL-2 and led to an overall reduction in BCL-2 levels
Deng et al., Blood 2009
(Hematologic Neoplasms) :
By contrast, treatment of cells with C2-ceramide ( a potent PP2A activator ) or expression of the
PP2A catalytic subunit (PP2A/C) inhibits
Bcl2 phosphorylation, leading to increased p53/Bcl2 binding and apoptotic cell death ... Mechanistically,
PP2A mediated dephosphorylation of Bcl2 in vitro promotes its direct interaction with p53 as well as a conformational change in
Bcl2