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PTK2B — VEGFA

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PTK2B → VEGFA (increases)
  Evidence: VEGF also stimulates tyrosine phosphorylation of Pyk2
• NCI Pathway Database Integrins in angiogenesis: alphav/beta3 Integrin/VEGFR2/VEGFA (dimer) complex (KDR-VEGFA-ITGAV-ITGB3) → PYK2 (PTK2B) (modification, activates) Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay
• Reactome Reaction: PTK2B → VEGFA (reaction) Butler et al., J Biol Chem 2005, Le Boeuf et al., Mol Biol Cell 2006
• Reactome Reaction: PTK2B → VEGFA (indirect_complex) Butler et al., J Biol Chem 2005

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• STRING interaction: PTK2B — VEGFA (interaction, mapped from bind kegg_pathways dip)
• STRING interaction: VEGFA — PTK2B (interaction, mapped from kegg_pathways mint)

Text-mined interactions from Literome

Matsui et al., Circulation 2007 (Ischemia) : PI3-kinase is associated with vascular endothelial growth factor induced PYK2/Src complex, and inhibition of Src blocked Akt activation
Liu et al., Blood 1997 : These results suggest that, in marrow endothelium, activation of RAFTK by VEGF , VRP, OSM, and bFGF represents a new element in the signal transduction pathways used by these growth factors and likely acts to coordinate signaling from their surface receptors to the cytoskeleton, thereby modulating cell growth and function