Gene interactions and pathways from curated databases and text-mining

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CEBPB — CREB5

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Zhang et al., J Biol Chem 2004 : Role of CREB in transcriptional regulation of CCAAT/enhancer binding protein beta gene during adipogenesis ... Consistent with the interaction of CREB and ATF1 at the TGA regulatory elements, expression of constitutively active CREB strongly activated C/EBPbeta promoter-reporter genes, induced expression of endogenous C/EBPbeta, and caused adipogenesis in the absence of the hormonal inducers normally required ... Conversely, expression of a dominant negative CREB blocked promoter-reporter activity, expression of C/EBPbeta , and adipogenesis
Fox et al., J Biol Chem 2006 : Depletion of CREB/ATF1 did not suppress the expression of C/EBP beta as we had previously observed using dominant negative forms of CREB
Karamitri et al., J Biol Chem 2009 : Forskolin stimulation and C/EBPbeta overexpression in 3T3-L1 cells increased C/EBPbeta and CREB but displaced ATF-2 and CHOP10 binding to the Pgc-1alpha proximal CRE
Ruffell et al., Proc Natl Acad Sci U S A 2009 : CREB mediated induction of Cebpb expression is therefore required in infiltrating macrophages for upregulation of M2-specific genes and muscle regeneration, providing a direct genetic link between these two processes