Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
JAK2
→
RHOA
(increases, RHOA Activity, JAK2 Activity)
Evidence: Here we report a novel signaling pathway whereby RhoA can efficiently modulate Stat3 transcriptional activity by inducing its simultaneous tyrosine and serine phosphorylation. Tyrosine phosphorylation is exerted via a member of the Src family of kinases (SrcFK) and JAK2, whereas the JNK pathway mediates serine phosphorylation.
OpenBEL Selventa BEL large corpus:
JAK2
→
RHOA
(increases, RHOA Activity, JAK2 Activity)
Benitah et al., Mol Biol Cell 2003* Evidence: Here, we provide evidence that Rho GTPases modulate Stat5a, a transcription factor of the family of signal transducers and activators of transcription. RhoA triggers tyrosine phosphorylation (Y696) of Stat5a via a JAK2-dependent mechanism and promotes DNA-binding activity of Stat5a.