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MAPK1 — SMAD2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: SMAD2 → MAPK1 (increases, SMAD2 Activity) Kretzschmar et al., Genes Dev 1999*
  Evidence: Ras acting via Erk MAP kinases causes phosphorylation of Smad2 and Smad3 at specific sites in the region linking the DNA-binding domain and the transcriptional activation domain.
• KEGG TGF-beta signaling pathway: MAPK1/MAPK3 → Complex of SMAD2-SMAD3-SMAD4 (protein-protein, inhibition)
  
• NCI Pathway Database Regulation of cytoplasmic and nuclear SMAD2/3 signaling: Erk1-2-active (MAPK3/MAPK1) → SMAD2 (SMAD2) (modification, activates) Funaba et al., J Biol Chem 2002*, de Caestecker et al., Genes Dev 1998*
  Evidence: mutant phenotype, assay, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• Gene Ontology Complexes protein complex: protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3) Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998
• IRef Hprd Interaction: SMAD2 — MAPK1 (in vitro) Kretzschmar et al., Genes Dev 1999*
• IRef Intact Interaction: Complex of 48 proteins (physical association, tandem affinity purification) Brown et al., J Cell Biochem 2008

Text-mined interactions from Literome

Wrana et al., Science's STKE : signal transduction knowledge environment 2000 : In the cytosol, Smad translocation might be inhibited by mitogen activated protein kinase dependent phosphorylation, whereas in the nucleus Smads interact with a number of transcription factors that themselves are primary targets of other signaling pathways
Yang et al., Am J Pathol 2003 (Fibrosis) : Inhibition of Erk-1/2 activation by Mek kinase inhibitor PD98059 restored TGF-beta1 mediated Smad-2/3 nuclear accumulation and myofibroblast activation
Lee et al., Int J Oncol 2004 (Stomach Neoplasms) : Smad2 mediates Erk1/2 activation by TGF-beta1 in suspended, but not in adherent, gastric carcinoma cells ... In this study, we examined effects of cell adhesion status on the TGF-beta1 mediated Erk1/2 regulation, and roles of Smad proteins on the cell adhesion mediated effects, using a gastric carcinoma cell variant
Rhyu et al., J Am Soc Nephrol 2005 (Fibrosis...) : Chemical inhibition of ERK but not p38 MAPK inhibited TGF-beta1 induced Smad 2 phosphorylation, and both MAPK inhibitors inhibited TGF-beta1- and H ( 2 ) O ( 2 ) -induced EMT
Galliher et al., Cancer Res 2007 (MAP Kinase Signaling System...) : Interestingly, although the expression of Y284F-TbetaR-II mutants in breast cancer cells had no effect on TGF-beta stimulation of Smad2/3 , this TbetaR-II mutant completely abrogated p38 MAPK activation by TGF-beta
Zhao et al., Mol Cell Biochem 2008 (Fibrosis...) : Additionally, the inhibition of MAPK signaling had no effect on Smad activation elicited by chymase
Zhang et al., Exp Dermatol 2009 (Fibrosis) : Activation of Smad2 required p38 MAPK but not p42/p44 MAPK or the epidermal growth factor receptor
Schievenbusch et al., Biochem Biophys Res Commun 2009 (Fibrosis) : As previously shown, Erk1/2 phosphorylation results in Smad-linker phosphorylation, thereby antagonizing cellular signals induced by TGFbeta
Zhu et al., Prostate 2010 (MAP Kinase Signaling System) : These findings suggest a dual role for PHB as a downstream determinant of the cellular response to TGF-beta via Smad dependent pathway ( apoptosis ) and MAPK intracellular signaling ( survival )
Rodrigues Díez et al., PloS one 2010 (Fibrosis) : In cultured rat VSMCs, direct AngII/Smad pathway activation was mediated by p38 MAPK and ROCK activation
Ungefroren et al., Int J Oncol 2011 (Carcinoma, Pancreatic Ductal...) : Biochemically, dnSrc inhibition failed to block TGF-ß1/ALK5 induced activation of Smad2 and Smad3, but partially inhibited transcriptional activation of TGF-ß/Smad-responsive reporter genes, and effectively blocked basal and TGF-ß1 induced activation of p38 MAPK
Mottershead et al., Mol Hum Reprod 2012 : The GDF9/BMP15 synergistic signalling response was inhibited by the SMAD2/3 phosphorylation inhibitor SB431542, as well as inhibition of the mitogen activated protein kinase or rous sarcoma oncogene (SRC) signalling pathways, but not the nuclear factor kappa B pathway
Liu et al., J Agric Food Chem 2012 (Carcinoma, Non-Small-Cell Lung...) : EGCG decreased the phosphorylation of Smad2 and Erk1/2 , inhibited the nuclear translocation of Smad2 , and repressed the expression of transcription factors ZEB1, Snail, Slug, and Twist, and up-regulated the expression of E-cadherin