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IL12A — RABEPK
Text-mined interactions from Literome
Nagayama et al., J Immunol 2000
:
Furthermore, stimulation of DCs with
IL-12 induced
IL-12p40 transcript, but not IL-12p35 transcript, whereas this stimulation caused the expressions of both transcripts in Con A blasts
Taoufik et al., Eur J Immunol 2001
:
IL-12p70 and, more effectively, the combination of IL-12p70 and IFN-gamma,
induced IL-12p40 mRNA expression and bioactive IL-12p70 production
Yang et al., Neuroendocrinology 2002
:
Both
IL-12 p40 gene
induction and IL-12 production were also observed when freshly isolated pituitary glands from non treated SD rats were incubated with LPS in vitro
Masumi et al., FEBS Lett 2002
:
We have previously shown that
IL-12p40 expression is impaired in ICSBP-deficient mice and that transfection of ICSBP together with IRF-1 can
activate IL-12p40 expression in mouse macrophage cells
Hensler et al., J Gen Virol 2009
:
We detected expression of interleukin (IL)-6, tumour necrosis factor (TNF)-alpha, macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, RANTES and IL-12p40 from 2 to 6 h post-infection, and these peaked by 15-24 h. Expression of these factors decreased 24-48 h post-infection, with the exception of TNF-alpha which remained high throughout the entire 72 h. Interestingly, while
IL-12p40 expression increased post-infection, bioactive
IL-12p70 was not
detected in the supernatants
Gulliver et al., Am J Respir Cell Mol Biol 2011
(Asthma) :
The B(1)R agonist Lda-BK was not chemotactic for hMo-DCs matured using LPS, TNF-a + IL-1ß, or CD40 ligand, but Lda-BK enhanced the secretion of
IL-12p70 and
inhibited the secretion of
IL-12p40 by mature hMo-DCs
Kricek et al., Eur J Immunol 1995
:
After GAMD injection, two groups of induction profiles were observed in spleen, mesenteric lymph nodes and Peyer 's patches : while IL-4 and
IL-12p35 gene transcription was strongly enhanced, IFN-gamma,
IL-12p40 and IL-13 mRNA were only moderately
induced
Hayes et al., Blood 1995
:
These results indicated that both
p40 and p35 are LPS-inducible in monocytes following IFN-gamma pretreatment, and that the regulated expression of p35
controls the level of active
IL-12 protein in purified human monocytes
Mattner et al., Eur J Immunol 1993
:
Only IL-2 +
IL-12 but not IL-2 + tumor necrosis factor induced aggregation was
inhibited in a dose dependent manner by
IL-12p40
Chong et al., Infect Immun 1996
:
By 4 h postexposure, viable organisms had
induced a 27-fold increase in
IL-12 p40 mRNA levels while killed organisms had induced a 9-fold increase in IL-12
p40 mRNA levels
von Stebut et al., J Exp Med 1998
(Leishmaniasis, Cutaneous) :
Parasite internalization was associated with activation manifested by upregulation of major histocompatibility complex ( MHC ) class I and II surface antigens, increased expression of costimulatory molecules ( CD40, CD54, CD80, and CD86 ), and interleukin (IL)-12
p40 release within 18 h. L. major
induced IL-12 p70 release by DC required interferon gamma and prolonged ( 72 h ) incubation