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Hoon Kim et al., Biochem Biophys Res Commun 2003
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We previously demonstrated caspase mediated cleavage of p130cas during apoptosis and identified two caspase-3 cleavage sites [ 1 ]
Kim et al., J Biol Chem 2004
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During apoptosis, caspase mediated cleavage of p130 ( cas ) generated a C-terminal 31-kDa fragment ( 31-kDa ) and promoted morphological changes characteristic of apoptosis, including loss of focal adhesions, cell rounding, and nuclear condensation and fragmentation