◀ Back to TP53
POU4F1 — TP53
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Direct p53 effectors:
POU4F1 (POU4F1)
→
p53 (tetramer) complex (TP53)
(transcription, activates)
Le Cam et al., Cell 2006, Harms et al., Cancer Res 2007, Shi et al., Mol Cell 2007, Das et al., Cell 2007, Xu et al., J Biol Chem 2007, Gamper et al., Mol Cell Biol 2008, el-Deiry et al., Cancer Res 1995
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Direct p53 effectors:
POU4F1 (POU4F1)
→
p53 (tetramer) complex (TP53)
(transcription, activates)
Budhram-Mahadeo et al., J Biol Chem 1999*
Evidence: mutant phenotype, reporter gene, physical interaction, other species
-
NCI Pathway Database Direct p53 effectors:
POU4F1 (POU4F1)
→
p53 (tetramer) complex (TP53)
(transcription, inhibits)
Hudson et al., J Biol Chem 2005
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Direct p53 effectors:
POU4F1 (POU4F1)
→
p53 (tetramer) complex (TP53)
(transcription, activates)
Harms et al., Cancer Res 2007, Shi et al., Mol Cell 2007, Das et al., Cell 2007, Xu et al., J Biol Chem 2007, Gamper et al., Mol Cell Biol 2008, Tang et al., Cell 2008, el-Deiry et al., Cancer Res 1995
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Direct p53 effectors:
POU4F1 (POU4F1)
→
p53 (tetramer) complex (TP53)
(transcription, activates)
Harms et al., Cancer Res 2007, Shi et al., Mol Cell 2007, Das et al., Cell 2007, Xu et al., J Biol Chem 2007, Gamper et al., Mol Cell Biol 2008, Jansson et al., Nat Cell Biol 2008, el-Deiry et al., Cancer Res 1995
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Direct p53 effectors:
POU4F1 (POU4F1)
→
p53 (tetramer) complex (TP53)
(transcription, inhibits)
Shikama et al., Mol Cell 1999, Thornborrow et al., J Biol Chem 2001, Thornborrow et al., Oncogene 2002, Hudson et al., J Biol Chem 2005, Sykes et al., Mol Cell 2006
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Direct p53 effectors:
POU4F1 (POU4F1)
→
p53 (tetramer) complex (TP53)
(transcription, inhibits)
Thornborrow et al., J Biol Chem 2001, Thornborrow et al., Oncogene 2002, Hudson et al., J Biol Chem 2005, Budhram-Mahadeo et al., Nucleic Acids Res 2006*, Sykes et al., Mol Cell 2006
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Direct p53 effectors:
POU4F1 (POU4F1)
→
p53 (tetramer) complex (TP53)
(transcription, inhibits)
Thornborrow et al., J Biol Chem 2001, Samuels-Lev et al., Mol Cell 2001, Thornborrow et al., Oncogene 2002, Hudson et al., J Biol Chem 2005, Sykes et al., Mol Cell 2006
Evidence: mutant phenotype, reporter gene, physical interaction
Text-mined interactions from Literome
Budhram-Mahadeo et al., J Biol Chem 1999
:
The significance of these effects is discussed in terms of the antagonistic
effects of Bcl-2 and
p53 on the rate of apoptosis and the overexpression of
Brn-3a in specific tumor cell types
Budhram-Mahadeo et al., Neurosci Lett 2002
(Carcinoma, Squamous Cell...) :
Thus, in co-transfection experiments,
Brn-3a activates the
p53 promoter acting via a region from +22 to +67, located between the most proximal ( +1 ) and the most distal ( +105 ) transcriptional start sites ... Similarly, reduction of
Brn-3a expression using anti-sense constructs
reduces endogenous
p53 expression in human neuroblastoma or cervical carcinoma cell lines growing in vitro and as tumours in nude mice whilst increasing Brn-3a levels enhances p53 expression ... These results suggest the existence of a negative feedback loop in which elevated
Brn-3a expression
induces the expression of
p53 which, in turn, antagonises the anti-apoptotic activity of Brn-3a
Perez-Sanchez et al., Nucleic Acids Res 2002
:
Thus,
Brn-3a inhibits activation of the Bax promoter by
p53 but enhances the ability of p53 to activate the p21 promoter
Hudson et al., J Biol Chem 2005
:
Brn-3a differentially
regulates p53 mediated gene expression and modifies its effect on cell fate