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IL1B — TLR2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IL1B → TLR2 (increases, IL1B Activity) Aliprantis et al., EMBO J 2000*
  Evidence: These data indicate that TLR2 is a novel 'death receptor' that engages the apoptotic machinery without a conventional cytoplasmic death domain. Through TLR2, BLP induces the synthesis of the precursor of the pro-inflammatory cytokine interleukin-1beta (IL-1beta).
• OpenBEL Selventa BEL large corpus: IL1B → TLR2 (increases, IL1B Activity) Aliprantis et al., EMBO J 2000*
  Evidence: Modified assertion
• OpenBEL Selventa BEL large corpus: TLR2 → IL1B (increases)
  Evidence: Type-1 cytokines including IL-1?, TNF-? and IFN-? induced a strong up-regulation of TLR2 mRNA (Fig. 8) and protein expression that was most pronounced by the co-stimulation with TNF-? and IFN-? (Fig. 5).

Text-mined interactions from Literome

Oshikawa et al., Biochem Biophys Res Commun 2003 (Lung Diseases) : The results demonstrated three patterns of gene expression : the TLR2 and myeloid differentiation factor 88 ( MyD88 ) gene expressions were induced in AM in response to lipopolysaccharide (LPS), interleukin (IL)-1beta , or tumor necrosis factor-alpha or in the lung tissue of an LPS induced acute lung injury model ; the gene expressions of TLR1, -3, -6, CD14, and MD2 were unchanged ; and the TLR4 and TLR5 gene expressions were downregulated in AM following inflammatory stimuli
Sakai et al., BMC molecular biology 2004 : Glucocorticoids synergistically enhance IL-1beta induced TLR2 expression via specific up-regulation of the MAP kinase phosphatase-1 that, in turn, leads to dephosphorylation and inactivation of both MAPK JNK and p38, the negative regulators for TLR2 induction
Hajishengallis et al., Infect Immun 2005 : Induction of interleukin-1beta (IL-1beta) , IL-6, IL-8, or tumor necrosis factor alpha in human THP-1 cells by LT-IIaB or LT-IIbB was inhibited by anti-TLR2 but not by anti-TLR4 antibody
Su et al., Osteoarthritis Cartilage 2005 (Osteoarthritis, Knee) : Expression and regulation of Toll-like receptor 2 by IL-1beta and fibronectin fragments in human articular chondrocytes
Ozören et al., J Immunol 2006 : Distinct roles of TLR2 and the adaptor ASC in IL-1beta/IL-18 secretion in response to Listeria monocytogenes ... These results demonstrate that TLR2 and ASC regulate the secretion of IL-1beta via distinct mechanisms in response to Listeria
Toshchakov et al., J Immunol 2007 (MAP Kinase Signaling System) : TLR2- and TLR4-BB peptides ( BBPs ) inhibited NF-kappaB translocation and early IL-1beta mRNA expression induced by LPS, and the lipopeptides S- [ 2,3-bis ( palmitoyloxy ) - ( 2-RS ) -propyl ] -N-palmitoyl- ( R ) -Cys-Ser-Lys ( 4 ) -OH ( P3C ) and S- [ 2,3-bis ( palmitoyloxy ) - ( 2-RS ) -propyl ] -Cys-Ser-Lys ( 4 ) -OH ( P2C )
Chang et al., Invest Ophthalmol Vis Sci 2007 (Acute Disease...) : In contrast, significantly increased production of IL-1beta in response to TLR2 stimulation was observed in patients with AAU ( P < 0.05 )
Li et al., J Immunol 2007 : Alum induced IL-1beta and IL-18 production was not due to enhancement of TLR signaling but rather reflected caspase-1 activation and in mouse dendritic cells occurred in a MyD88 independent fashion
Dinarello et al., Immunity 2007 (Inflammation) : Secretion of the proinflammatory cytokine IL-1beta requires caspase-1 and Toll-like receptor ( TLR ) signaling
Kim et al., Immunol Lett 2007 (Arthritis, Rheumatoid...) : TLR stimulation of RA-FLS also induced the production of IL-1beta and TNF-alpha to a lesser extent ; however, it had no effect on IL-17 production ... Inhibition of TLR induced IL-1beta production, which partially reversed the upregulation of RANKL induced by TLR ligands
Ferwerda et al., J Leukoc Biol 2007 (Crohn Disease) : TLR induced TNF-alpha, IL-1beta , and IL-10 production is mediated through MyD88, whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta
Villacres et al., J Viral Hepat 2008 (Hepatitis C, Chronic) : To a lesser extent, tumour necrosis factor-alpha and IL-1beta responses to TLR stimulation were also compromised
Büchau et al., J Invest Dermatol 2008 : Pimecrolimus also increased the functional capacity of keratinocytes to inhibit growth of Staphylococcus aureus and decreased TLR2/6 induced expression of IL-10 and IL-1beta
Wikén et al., J Clin Immunol 2009 (Sarcoidosis) : Combined TLR2 and NOD2 stimulation induced a four-fold higher secretion of TNFalpha and a 13-fold higher secretion of IL-1 beta in patients
Netea et al., Expert Opin Biol Ther 2008 (Inflammation) : Monocytes can release active IL-1 beta upon stimulation with TLR ligands alone
van de Veerdonk et al., J Infect Dis 2009 (Inflammation) : The transcription of IL-1beta was induced through mannose receptor ( MR ), Toll-like receptor (TLR) 2 , and dectin-1 but not through TLR4 and TLR9
Hurst et al., Immunobiology 2009 (Antiphospholipid Syndrome) : Determination of expression-levels using real-time RT-PCR showed significantly augmented TLR dependent IL-1beta and caspase-1 expression
Jung et al., Immunol Lett 2009 (Arthritis, Experimental...) : These data show that TLR2, TLR4 , and TLR6 ligation synergistically stimulates the production of TNF-alpha and IL-1beta in IL-1Ra-deficient mice and suggest that TLRs contribute to the perpetuation of spontaneous arthritis in this animal model ... These data show that TLR2 , TLR4, and TLR6 ligation synergistically stimulates the production of TNF-alpha and IL-1beta in IL-1Ra-deficient mice and suggest that TLRs contribute to the perpetuation of spontaneous arthritis in this animal model
Jie Zhao et al., Innate Immun 2009 (Aspergillosis...) : Aspergillus fumigatus keratitis developed in Wistar rats, as evidenced by high SLE scores, influx of polymorphonuclear leukocytes ( PMNs ), activation of TLR2 and TLR4, and production of IL-1beta and IL-10 over controls
Liu et al., PloS one 2009 : TLR2/1 activation triggered IL-1beta activity, involving the upregulation of both IL-1beta and IL-1 receptor, and downregulation of the IL-1 receptor antagonist
Lamkanfi et al., J Biol Chem 2009 (Inflammation) : IL-1beta secretion further required the Toll-like receptor ( TLR ) adaptors MyD88 and TRIF, and partially relied on TLR2
Delaloye et al., PLoS Pathog 2009 : Transcription of the Il1b gene was markedly impaired in TLR2 ( -/- ) and MyD88 ( -/- ) BMDM, whereas mature and secreted IL-1beta was massively reduced in NALP3 ( -/- ) BMDMs or in human THP-1 macrophages with reduced expression of NALP3, ASC or caspase-1 by shRNAs
Kleinnijenhuis et al., Eur J Immunol 2009 : In contrast, TLR4 , TLR9 and TLR1 receptors are not involved in IL-1beta induction
Enstrom et al., Brain Behav Immun 2010 : In particular, there was a marked increase in pro-inflammatory IL-1beta, IL-6, and TNFalpha responses following TLR 2 , and IL-1beta response following TLR 4 stimulation in monocyte cultures from children with ASD ( p < 0.04 )
Böni-Schnetzler et al., Endocrinology 2009 : FFA induced IL-1beta and KC expression in mouse islets was completely dependent on the IL-1R/Toll-like receptor ( TLR ) docking protein Myd88 and partly dependent on TLR2 and -4 ... FFA induced IL-1beta and KC expression in mouse islets was completely dependent on the IL-1R/Toll-like receptor ( TLR ) docking protein Myd88 and partly dependent on TLR2 and -4
Mayer-Barber et al., J Immunol 2010 (Tuberculosis, Pulmonary) : Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo
He et al., J Immunol 2010 (Chlamydia Infections...) : TLR2 was required for induction of pro-IL-1beta , whereas the NLRP3/ASC was required for caspase-1 activation and pro-IL-1beta cleavage to produce mature IL-1beta