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PTGS2 — RHOA
Text-mined interactions from Literome
Thomas et al., Infect Immun 2001
:
Cytotoxic necrotizing factor from Escherichia coli induces
RhoA dependent expression of the
cyclooxygenase-2 Gene
Schmeck et al., Inflammation 2003
:
Therefore,
RhoA/Rac1/Cdc42 contribute to NF-kappaB dependent LPS- and TNFalpha induced expression of
PGHS-2 in EC but had no effect on the activity of expressed COX-1 and COX-2
Chang et al., J Cell Biochem 2005
:
Differential
regulation of
cyclooxygenase 2 expression by small GTPases Ras, Rac1, and
RhoA ... Individual expression of constitutively active Ras,
RhoA , or Rac1 was capable of stimulating COX-2 expression in NIH3T3 cells, but co-expression of constitutively active RhoA with either constitutively active Ras or Rac1 was
required for full stimulation of
COX-2 expression ... PD98059 only inhibited constitutively active Ras induced COX-2 expression, while SP600125 significantly inhibited both constitutively active Ras- and
RhoA induced
COX-2 expression ... Together, our data suggest that constitutively active oncogenic Ras and Rho coordinately stimulate COX-2 expression whereas transient activation of Ras but not
RhoA or Rac1
mediates the induction of
COX-2 in response to serum ... Furthermore, ERK and JNK activation are both required for serum- and oncogenic Ras mediated COX-2 expression whereas only JNK activation is required for oncogenic
RhoA mediated stimulation of
COX-2 expression
Chang et al., Cancer Res 2006
(Colonic Neoplasms...) :
RhoA mediates
cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility ... Inhibition of
COX-2 significantly
reduced the levels of
RhoA activity in HCA-7 cells, suggesting that constitutive expression of COX-2 stimulates RhoA activity