◀ Back to RHOA
PTPN1 — RHOA
Text-mined interactions from Literome
Kabuyama et al., Mol Cell Proteomics 2006
:
Subsequent analysis demonstrated that
RhoA enhances post-translational modification of
PTP1B , inactivates phosphotyrosine phosphatase activity, and up-regulates tyrosine phosphorylation of p130Cas, a key mediator of focal adhesion turnover and cell migration
Burdisso et al., J Cell Sci 2013
:
Pull-down and FRET analysis also showed that
PTP1B is
required for efficient integrin dependent downregulation of
RhoA and upregulation of Rac1 during spreading