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EPHB2 — NPPA

Text-mined interactions from Literome

Pandey et al., Biochem Biophys Res Commun 2000 : We have examined the effect of atrial natriuretic peptide (ANP) and its guanylyl cyclase/natriuretic peptide receptor-A (NPRA) on mitogen activated protein kinase/extracellular signal regulated kinase 2 ( MAPK/ERK2 ) activity in rat mesangial cells overexpressing NPRA ... ANP inhibited agonist stimulated activity of MAPK/ERK2 by 65-75 % in cells overexpressing NPRA, whereas in vector transfected cells, its inhibitory effect was only 18-20 % ... NPRA antagonist A71915 and KT5823, a specific inhibitor of cGMP dependent protein kinase ( PKG ) completely reversed the inhibitory effect of ANP on MAPK/ERK2 activity
Ueyama et al., J Mol Cell Cardiol 2000 (Cardiomegaly...) : Overexpression of MEK1 EE in MCs activated ERK1/2 and subsequently induced atrial natriuretic peptide (ANP) mRNA expression
Kook et al., Am J Physiol Heart Circ Physiol 2003 : ANP increased the expression of phospho-Akt and of phospho-ERK1/2 within 1.5 h
Müller et al., Endocrinology 2006 (Leydig Cell Tumor) : LPA, but not ANP , enhances ERK phosphorylation and induces cell rounding together with a dramatic reorganization of actin filaments
You et al., Endocrinology 2009 : In contrast, ANP reduced the levels of phospho-ERK in INS-1E cells
O'Tierney et al., J Physiol 2010 : Ang II-stimulated ERK and Akt phosphorylation was inhibited by 100 nm ANP
Isono et al., Kidney Int 1998 : We have reported that both extracellular signal regulated kinase ( ERK ) and c-Jun NH2-terminal kinase (JNK) are activated by ET-1 and ET-1 induced activation of ERK is inhibited by ANP