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SLC22A3 — ZEB2
Text-mined interactions from Literome
Vandewalle et al., Nucleic Acids Res 2005
:
SIP1/ZEB2 induces
EMT by repressing genes of different epithelial cell-cell junctions
Chua et al., Oncogene 2007
(Cell Transformation, Neoplastic...) :
MCF10A cells chronically exposed to tumor necrosis factor alpha (TNFalpha), a potent NF-kappaB inducer, also exhibited the
EMT-like phenotype and
ZEB-1/ZEB-2 induction , both of which were reversed following TNFalpha withdrawal
Kong et al., Stem Cells 2009
(Neoplasm Invasiveness...) :
Recent studies have shown that the miR-200 family
regulates epithelial-mesenchymal transition (EMT) by targeting zinc-finger E-box binding homeobox 1 ( ZEB1 ) and
ZEB2
Peña et al., Oncogene 2009
(Carcinoma...) :
SNAI1,
ZEB1 , E-cadherin ( CDH1 ), and vitamin D receptor (VDR) genes
regulate the
epithelial-mesenchymal transition (EMT) that initiates the invasion process of many tumor cells
Namba et al., Cell Death Differ 2010
(Pulmonary Fibrosis) :
Smad interacting protein 1 ( a transcription factor
regulating EMT ) and the Notch signaling pathway but not transforming growth factor-ß was shown to be involved in A771726 induced EMT-like phenotypes
Brabletz et al., EMBO Rep 2010
(Neoplasms) :
Zinc-finger enhancer binding ( ZEB ) transcription factors ( ZEB1 and ZEB2 ) are crucial
EMT activators , whereas members of the miR-200 family induce epithelial differentiation
Oba et al., PloS one 2010
(Fibrosis...) :
miR-200 family members have been previously shown to
inhibit EMT by reducing the expression of ZEB-1 and
ZEB-2 which are known repressors of E-cadherin
Stinson et al., Science signaling 2011
(Breast Neoplasms...) :
TRPS1
inhibited EMT by directly repressing expression of
ZEB2 ( Zinc finger E-box binding homeobox 2 )