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NTN1 — RHOA

Pathways - manually collected, often from reviews:

• NCI Pathway Database Netrin-mediated signaling events: netrin 1/DCC/FAK/Fyn complex (NTN1-DCC-PTK2-FYN) → RHOA/GTP complex (RHOA) (modification, activates) Moore et al., Development 2008, Rajasekharan et al., Development 2009, Rajasekharan et al., J Neurochem 2010
  Evidence: mutant phenotype
• NCI Pathway Database Netrin-mediated signaling events: RHOA/GDP complex (RHOA) → netrin 1/UNC5A complex (NTN1-UNC5A) (modification, collaborate)
  Picard et al., Cell Signal 2009*
  Evidence: mutant phenotype

Text-mined interactions from Literome

Moore et al., Development 2008 : Here, we show that netrin 1 , through its receptor DCC, inhibits RhoA in embryonic spinal commissural neurons
Picard et al., Cell Signal 2009 : In fibroblasts, UNC5a was able to activate RhoA and to a lower extent Rac1 and Cdc42 in response to netrin-1
Rajasekharan et al., J Neurochem 2010 : In OPCs, we show that netrin-1 induces a sustained increase in RhoA activity that requires Deleted in Colorectal Cancer function