Suzuki et al., Genes Dev 2002
(Cell Transformation, Neoplastic) :
Thus, Tob inhibits cell growth by suppressing cyclin D1 expression, which is canceled by Erk1- and Erk2 mediated Tob phosphorylation
Yoshida et al., Genes Dev 2003
(Genetic Predisposition to Disease...) :
Tob acts as a transcriptional corepressor and suppresses the cyclin D1 promoter activity through an interaction with histone deacetylase
Hiramatsu et al., Cancer Res 2006
:
Tob1 , a member of the Tob/BTG family, is involved in the control of G ( 1 ) -S progression by suppressing cyclin D1 expression and acts as a tumor suppressor gene