Gene interactions and pathways from curated databases and text-mining

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APC — IL6

Text-mined interactions from Literome

Zhong et al., Anesthesiology 2004 (Myocardial Infarction...) : APC with sevoflurane attenuated NF-kappaB activation and reduced the expression of tumor necrosis factor alpha, interleukin 1, intercellular adhesion molecule 1, and inducible nitric oxide synthase
Xue et al., Exp Cell Res 2004 : APC also significantly increased the production of IL-6 and IL-8 and suppressed calcium- and LPS stimulated NF-kappaB activity
Mehrotra et al., Immunology 2004 (Melanoma) : Among the various microenvironmental factors, interleukin-10 (IL-10) exhibits a potent immunosuppressive effect on antigen presenting cells (APC)
Li et al., J Zhejiang Univ Sci B 2006 : APC can further increase the level of IL-6 and IL-8 induced by LPS
Wang et al., Journal of thrombosis and haemostasis : JTH 2011 (MAP Kinase Signaling System...) : Moreover, both APC and APC-2Cys inhibited production of TNFa and IL-6 in vivo by attenuating the ischemia/reperfusion induced JNK and NF-?B signaling pathways
Piuvezam et al., J Immunol 1993 : T cell lines generated against Tct proliferated in response to parasite lysate only in the presence of autologous APC and produced IL-2, IL-6 , and IFN-gamma but not IL-4 in response to PMA plus ionomycin
Gray et al., Haemostasis 1996 : Activated protein C (APC) augmented LPS stimulation of HUVEC and further increased the production of tissue factor and IL-6
Behboudi et al., Cytokine 1997 : Among the various combinations of QH-A and QH-C tested and also the original semipurified spikoside, the QH 7.0.3 matrix was the most efficient formulation for activation of IL-6 production by APC
Morein et al., Dev Biol Stand 1998 : Further, iscoms induce APC to produce IL-1, IL-6 and IL-12 and a TH1 type of response with enhanced IL-2 and IFN-gamma production