◀ Back to EGFR

EGFR — STAM

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: STAM → EGFR (increases, STAM Activity) Steen et al., J Biol Chem 2002*
  Evidence: Using anti-phosphotyrosine antibodies for immunoprecipitation and one-dimensional gel electrophoresis, we have identified 10 proteins in the epidermal growth factor receptor signaling pathway, of which 8 have been shown previously to be involved in epidermal growth factor signaling. Most importantly, in addition to several known tyrosine phosphorylation sites, we have identified five novel sites on SHIP-2, Hrs, Cbl, STAM, and STAM2, most of which were not predicted to be phosphorylated.
• OpenBEL Selventa BEL large corpus: STAM → EGFR (increases, STAM Activity)
  Evidence: This is taken from supplemental table 2 from PMID 15951569 Cut-offs were 2.25 for increase and 0.5 for decrease LLID were found by converting from GI assession numbers in DAVID Spreadsheet is saved in the project folder for Cell Signaling Project # bduckworth
• Reactome Reaction: EGFR → STAM (indirect_complex) Rosenthal et al., J Biol Chem 1999, Klapisz et al., J Biol Chem 2002, Haglund et al., Proc Natl Acad Sci U S A 2002, Sigismund et al., Proc Natl Acad Sci U S A 2005, Haglund et al., EMBO Rep 2005
• Reactome Reaction: EGFR → STAM (reaction) Rosenthal et al., J Biol Chem 1999, Klapisz et al., J Biol Chem 2002, Haglund et al., Proc Natl Acad Sci U S A 2002, Sigismund et al., Proc Natl Acad Sci U S A 2005

Text-mined interactions from Literome

Mizuno et al., Mol Biol Cell 2003 : Overexpression of STAM proteins, but not their mutants lacking the ubiquitin binding activity, causes the accumulation of ubiquitinated proteins and ligand activated epidermal growth factor receptor on the early endosome
Berlin et al., J Biol Chem 2010 : Regulation of epidermal growth factor receptor ubiquitination and trafficking by the USP8·STAM complex