Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
Complex of ICAM2-ITGAL-ITGB2
→
CXCL8
(increases)
Evidence: Strong adhesion between leukocytes and endothelial cells is promoted by the induction of ICAM-1 on inflamed endothelium and the activation of a conformational change in LFA-1 and Mac-1 in response to chemokines.
OpenBEL Selventa BEL large corpus:
ITGB2
→
CXCL8
(increases, CXCL8 Activity)
Evidence: the CXC chemokine interleukin (IL)-8 rapidly promotes adhesive interactions of the ?2 integrin Mac-1 and its ligands on endothelial cells, suggesting that it promotes leukocyte recruitment to sites of inflammation in vivo.