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MYO6 — TP53

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MYO6 → TP53 (increases, TP53 Translocation, MYO6 Activity) Jung et al., Mol Cell Biol 2006*
  Evidence: Specifically, we show that myosin VI is induced by p53 and DNA damage in a p53-dependent manner. We found that p53 directly binds to, and activates, the promoter of the myosin VI gene. We also show that the intracellular localization of myosin VI is substantially altered by p53 and DNA damage in a p53-dependent manner such that the pool of myosin VI in endocytic vesicles, membrane ruffles, and cytosol migrates to the Golgi complex, perinuclear membrane, and nucleus.

Text-mined interactions from Literome

Jung et al., Mol Cell Biol 2006 : Specifically, we show that myosin VI is induced by p53 and DNA damage in a p53 dependent manner
Cho et al., J Biol Chem 2010 (Neoplasms) : Previously, we found that myosin VI is up-regulated in RKO, LS174T, and H1299 cells by DNA damage in a p53 dependent manner and mediates the pro-survival function of p53 ... We also found that the levels of myosin VI protein were markedly inhibited in MCF7 cells by wild-type p53 but not tumor derived mutant p53