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DHFR — PTX3

Text-mined interactions from Literome

Zink et al., Eur J Med Chem 2004 : Piritrexim ( PTX ) ( 1 ), a lipophilic inhibitor of the human dihydrofolate reductase , has been evaluated as an anticancer agent
Kwok et al., Br J Cancer 1992 (Leukemia L1210) : The ability of hypoxanthine ( HX ) to modulate the effects of two antifolates-ICI 198583 ( an inhibitor of thymidylate synthetase ) and piritrexim ( PTX , a lipophilic inhibitor of DHFR ) -was investigated using cultured mouse leukaemic cells, L1210