◀ Back to LEP

FGF23 — LEP

Text-mined interactions from Literome

Tsuji et al., J Bone Miner Res 2010 : Leptin stimulates fibroblast growth factor 23 expression in bone and suppresses renal 1alpha,25-dihydroxyvitamin D3 synthesis in leptin-deficient mice ... The main site of FGF-23 mRNA expression was the bone, and leptin markedly increased the FGF-23 mRNA level in ob/ob mice ... These results indicate that leptin directly stimulates FGF-23 synthesis by bone cells in ob/ob mice, suggesting that inhibition of renal 1,25 ( OH ) ( 2 ) D ( 3 ) synthesis in these mice is at least partly due to elevated bone production of FGF-23
Saini et al., Calcif Tissue Int 2013 (Bone Neoplasms...) : Although neither leptin nor interleukin-6 (IL-6) alone affects FGF23 expression, leptin treatment was found to potentiate 1,25 ( OH ) D upregulation of FGF23 in UMR-106 cells, whereas IL-6 treatment blunted this upregulation