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LEP — MMP2
Text-mined interactions from Literome
Park et al., Exp Mol Med 2001
(Arteriosclerosis...) :
Leptin also induced
increases of MMP-2,
MMP-9 , TIMP-1, and Up-regulated the human coronary artery smooth muscle cells ( HCASMCs )
Kume et al., J Histochem Cytochem 2002
:
Leptin enhanced the proliferation, migration, tube formation, and
matrix metalloproteinase-2 (MMP-2) activity of human endothelial cells ( HUVECs ) in vitro
Quinton et al., Am J Reprod Immunol 2003
:
Expression of leptin receptor isoforms in vitro : lack of
effects of
leptin on endometrial cytokine and
MMP production ... The
effect of
leptin on cell growth and on the production of cytokines [Leukaemia Inhibitory Factor (LIF), interleukin 6 and tumour necrosis factor-alpha ] and
matrix metalloproteinases ( MMP ) ( MMP2 and MMP-9 ) was also investigated ...
Leptin had no effect on cytokine and
MMP production by these cells
Schulz et al., Biol Reprod 2004
:
Our results suggest that
leptin may play a role in the establishment of the placenta during early pregnancy and that this function is
dependent on
MMP activity
Li et al., Diabetes 2005
:
In the present study, we determined the
effect of
leptin on human aortic smooth muscle cell ( HASMC ) proliferation and
matrix metalloproteinase (MMP)-2 expression, the signaling pathways mediating these effects, and the modulatory effect of metformin on these parameters ... Metformin also inhibited the
effect of
leptin on HASMC proliferation and
MMP-2 expression ... Overall, these results demonstrate that
leptin induced HASMC proliferation and
MMP-2 expression through a PKC dependent activation of NAD ( P ) H oxidase with subsequent activation of the ERK1/2/NF-kappaB pathways and that therapeutic metformin concentrations effectively inhibit these biological effects
Madani et al., Cardiovasc Res 2006
:
Accordingly, upon quantitative PCR analysis we found that
leptin increased expression of
matrix metalloproteinase-2 (MMP-2) ... Our findings show that
leptin regulates cell size,
stimulates MMP-2 expression, and alters the profile, but not the total content, of collagen in human cardiomyocytes
Moon et al., Biochem Biophys Res Commun 2007
:
Leptin induced
matrix metalloproteinase-2 secretion is suppressed by trans-10,cis-12 conjugated linoleic acid ... The present study is designed to evaluate whether trans-10,cis-12 conjugated linoleic acid ( t-CLA ) can suppress
leptin induced
MMP-2 secretion in 3T3-L1 cells ... However, increasing concentration of t-CLA significantly reduced
leptin induced
MMP-2 secretion and triglyceride ( TG ) content
Schram et al., J Mol Cell Cardiol 2008
:
Increased expression and cell surface localization of MT1-MMP plays a role in
stimulation of
MMP-2 activity by
leptin in neonatal rat cardiac myofibroblasts ... Here we investigated the
effects of
leptin , circulating levels of which are typically increased in obese individuals, on
MMP and collagen expression and MMP activity in isolated cardiac myofibroblasts
Yeh et al., Glia 2009
(Brain Neoplasms...) :
In addition, we found that the expression of matrix metalloproteinase-13 (MMP-13) but not of
MMP-2 and MMP-9 was increased in
response to
leptin stimulation
McMurtry et al., Clin Exp Metastasis 2009
(Breast Neoplasms...) :
Here we showed that
leptin increased the invasiveness and the
matrix metallo-proteinase-2 (MMP-2) activity of the MCF-7 breast cancer cell line ... Leptin stimulated the phosphorylation of extracellular signals regulated kinases, signal transducers and activators of transcription 3 and Jun N-terminal kinases (JNK) ; however, only inhibition of JNK decreased
leptin mediated activation of
MMP-2 ... Here we report the novel findings that
leptin increased invasion of breast cancer cells by activating JNK, resulting in increased
MMP-2 activity
Bao et al., Mol Biol Rep 2010
:
Leptin significantly
increased both gene and protein levels of MMP-2,
MMP-9 , cathepsin D, and collagen II, while decreased bFGF markedly in cartilage
Tao et al., Arterioscler Thromb Vasc Biol 2013
(Aortic Aneurysm, Abdominal...) :
Leptin and leptin receptor antigen were evident in all AAAs, and leptin,
MMP-9 , and MMP-12 mRNA was
increased relative to age matched nondilated controls