Gene interactions and pathways from curated databases and text-mining

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CCNA2 — NFKB1

Text-mined interactions from Literome

Guo et al., Mol Cell Biol 2003 (Adenocarcinoma...) : Inhibiting NF-kappa B transcriptional activity in MCF+FIR cells, by using mutant I kappa B alpha, inhibited radioresistance as well as reducing steady-state levels of MnSOD, 14-3-3 zeta, GADD153, cyclin A , and cyclin B1 mRNA
Bai et al., J Immunol 2010 : CCN1 regulates this genetic program through at least two distinct mechanisms : an immediate-early response resulting from direct activation of NF-kappaB by CCN1 , leading to the synthesis of cytokines including TNF-alpha and inflammatory protein 10 ; and a delayed response resulting from CCN1 induced TNF-alpha, which acts as an autocrine/paracrine mediator to activate the expression of other cytokines including IL-1beta and IL-6