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IL6 — PPARA

Text-mined interactions from Literome

Xu et al., Endocrinology 2001 : We therefore examined the effects of the PPARalpha activator fenofibrate and the GR activator dexamethasone on TNFalpha stimulated expression of IL-6 and vascular cell adhesion molecule-1 in vascular endothelial cells
Xu et al., J Steroid Biochem Mol Biol 2002 : Thus, RU486 has an antagonizing effect on PPARalpha mediated down-regulation of IL-6 in vascular ECs
Murakami et al., Eur J Pharmacol 2007 (Insulin Resistance) : As a result, the IL-6 produced by RAW264.7 cells is an inducer of TNFalpha expression in 3T3-L1 adipocytes, and the IL-6 secretion is inhibited by the activation of PPARalpha
Borland et al., Cell Signal 2011 : However, these studies demonstrate that stable over-expression of PPARß/d or PPAR? significantly increases the efficacy of ligand activation and represses UVB induced expression of tumor necrosis factor a (TNFa), interleukin 6 (IL6), or IL8 in HaCaT keratinocytes, thereby establishing an excellent model to study the functional role of these receptors in human keratinocytes
Martín et al., J Hypertens 2012 : In addition, pioglitazone increased the interleukin-1ß induced PPAR? mRNA levels
Bogacka et al., Reprod Biol 2012 : We observed an inhibitory ( after 6 h of incubation, p < 0.0001 ) and a stimulatory ( after 12 h of incubation, p < 0.05 ) effect of INF? ( 5 ng/ml ) or IL-6 ( 10 ng/ml ) on PPAR?1 gene expression
Parmentier et al., Biochem Pharmacol 1997 : It was found that IL-1beta and IL-6 both repress the induction of PPAR alpha expression exerted by the combined action of clofibric acid and dexamethasone
Staels et al., Nature 1998 (Coronary Disease...) : In these smooth-muscle cells, we find that PPARalpha ligands, and not PPARgamma ligands, inhibit interleukin-1 induced production of interleukin-6 and prostaglandin and expression of cyclooxygenase-2