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AGTR1 — IGF2

Text-mined interactions from Literome

van Eickels et al., Br J Pharmacol 2000 : The IGF-I induced overexpression of the IGF-IR was reduced by ACE inhibition with moexiprilat ( 10 ( -7 ) M ) by 79+/-7 % and by AT(1) receptor blockade with CV11974 ( 10 ( -7 ) M ) by 79+/-5 %
Müller et al., J Renin Angiotensin Aldosterone Syst 2000 : IGF-l induced up-regulation of the AT1-receptor maybe an important interaction by which cellular grow this modulated in the heart as well as in the vasculature
Yin et al., Int J Biochem Cell Biol 2003 : Besides coupling with heterotrimeric G proteins to activate phospholipase C-beta (PLC-beta), AT1R also activates receptor tyrosine kinases ( PDGF-R, EGF-R and IGF-R ) and non-receptor tyrosine kinases ( Src, Fyn, Yes, proline-rich tyrosine kinase 2 (Pyk2), focal adhesion kinase ( FAK ) and JAK2 )
Bäck et al., Growth Horm IGF Res 2009 : In PA both the IR and the IGF-IR was phosphorylated by their own ligand at 1 nM and in dPA the activation of both receptors was stimulated by IGF-I, but not insulin, at 1 nM
Al-Shoumer et al., Eur J Endocrinol 1996 (Hypopituitarism) : Compared to baseline, IGF-I levels increased significantly at 1 ( p = 0.0001 ), 2 ( p = 0.0004 ), 3 ( p = 0.006 ) and 4 years ( p = 0.002 )