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Russo et al., Endocrinology 2004
(Neuroblastoma) :
Leptin 's antiapoptotic activity required Janus kinase/STAT , MAPK, and phosphatidylinositol-3-kinase activation because the antiapoptotic effects of leptin were abolished, and caspase-3 immunoreactivity increased in the presence of the specific blockers AG490, U0126, or LY294002
Hussner et al., Mol Pharmacol 2012
(Neoplasms) :
Furthermore, inhibition of JAK-STAT signaling significantly reduced doxorubicin induced caspase 3 activation and desensitized HeLa cells to doxorubicin cytotoxicity
Chin et al., Mol Cell Biol 1997
:
We further demonstrated that both EGF and IFN-gamma induced caspase 1 ( interleukin-1beta converting enzyme [ ICE ] ) gene expression in a STAT dependent manner