Voisin et al., Am J Physiol Cell Physiol 2002
:
Activation of the G ( q ) -coupled ANG II receptor or G ( i ) -coupled lysophosphatidic acid receptor resulted in increased tyrosine phosphorylation and activation of EGFR Ohtsu et al., Arterioscler Thromb Vasc Biol 2005
(Cardiovascular Diseases) :
We have further demonstrated that the Rho/ROCK activation by Ang II requires protein kinase C-delta (PKCdelta) and proline-rich tyrosine kinase 2 (PYK2) activation, but not epidermal growth factor receptor transactivation
Chen et al., J Am Soc Nephrol 2006
(Hypertrophy...) :
Ang II did not transactivate EGFR in empty vector transfected LLCPKcl4 cells ( Vector/Cl4 )
Sandoval et al., Cell Signal 2011
(Hypertension) :
These results suggest that the enhanced levels of endogenous Ang II in VSMC from SHR, transactivate EGFR , which through MAP kinase signaling, enhance the expression of Gia proteins and associated adenylyl cyclase signaling