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CEBPA — PTGS2

Text-mined interactions from Literome

Yeo et al., J Biol Chem 2003 : In addition, Cox-2 promoter-luciferase reporters with alterations in predicted cis acting transcriptional regulatory elements revealed that C/EBP , Ets-1, NF-kappaB, and CREB binding sites are essential for optimal Cox-2 expression in response to CpG DNA
Tamura et al., J Mol Endocrinol 2003 (Endometrial Neoplasms) : Employing electrophoretic mobility shift assays, we demonstrated that increased functional binding of CCAAT/enhancer binding protein ( C/EBP)alpha , C/EBPbeta and upstream stimulatory factor-2 to the CRE and C/EBPalpha and C/EBPbeta to the NF-IL6 site were, at least in part, responsible for MECM induced COX-2 expression in ESC ... Moreover, overexpression of C/EBPalpha and C/EBPbeta significantly induced COX-2 promoter activity in ESC ... Collectively, these results suggest that the basal and MECM induced transcription of the COX-2 gene in ESC is regulated through a combination of the CRE and the NF-IL6 site by functional interactions of C/EBPalpha and C/EBPbeta
Joo et al., J Biol Chem 2004 : Concomitantly, C/EBP-beta becomes acetylated, and expression of the COX-2 gene increases
Wu et al., Arterioscler Thromb Vasc Biol 2005 (Cardiovascular Diseases) : In this review, the role of C/EBP in regulating COX-2 transcription is highlighted
Jeong et al., Biochem Biophys Res Commun 2007 : Site-specific mutation analyses confirmed that Rd-mediated transcriptional activation of COX-2 gene was regulated by C/EBP and CREB
Oyesanya et al., FASEB J 2008 (Ovarian Neoplasms) : The consensus sites for C/EBP in the Cox-2 promoter were essential for transcriptional activation of Cox-2 by LPA
Kundu et al., Cancer Lett 2009 (Skin Neoplasms) : Taken together, the above findings suggest that oligonol inhibits TPA induced COX-2 expression by blocking the activation of NF-kappaB and C/EBP via modulation of MAP kinases and suppresses chemically induced mouse skin tumorigenesis
Jeong et al., J Immunol 2009 (Arthritis, Rheumatoid) : Site directed mutagenesis revealed that Pin1 mediated transcriptional activation of COX-2 was coordinately regulated by NF-kappaB, CREB, and C/EBP
Han et al., Food Chem Toxicol 2010 : Thus, DHCT is an effective agent to attenuate COX-2 production mediated by the transcription factors C/EBP and AP-1, and these results enhance our understanding of the anti-inflammatory and anti-cancer properties by DHCT
Hossain et al., Journal of bioscience and bioengineering 2010 (Mechanotransduction, Cellular) : Compressive force inhibits adipogenesis through COX-2 mediated down-regulation of PPARgamma2 and C/EBPalpha ... In conclusion, compressive force inhibited adipogenesis by suppressing expression of PPARgamma2 and C/EBPalpha in a COX-2 dependent manner
Kim et al., J Biol Chem 1998 (Carcinoma, Squamous Cell...) : We also found that C/EBP isoforms are expressed differentially during mouse skin carcinogenesis, suggesting that overexpression of COX-2 in tumors may be caused by a change in C/EBP expression levels