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FGF8 — SHH
Text-mined interactions from Literome
Power et al., Dev Dyn 1999
(Abnormalities, Multiple...) :
Molecular analysis of RA-deficient limb buds revealed
enhanced gli-3 and reduced hoxd-12, hoxd-13,
shh , and fgf-4, while
fgf-8 , en-1, and wnt-7a expression remained unaltered
Deutsch et al., Development 2001
:
Cardiac mesoderm or
FGF induces the local expression of
sonic hedgehog , which in turn is inhibitory to pancreas but not to liver
Ohkubo et al., Neuroscience 2002
(Abnormalities, Drug-Induced...) :
Similarly, loss of
SHH expression in Shh mutant mice
leads to increased BMP signaling and loss of
Fgf8 expression in the prosencephalon
Aoto et al., Dev Biol 2002
:
Whereas Fgf8 expression was almost absent in Shh-/- mutants, it was up-regulated in Gli3-/- ; Shh-/- double mutants, suggesting that
SHH is not
required for
Fgf8 induction, and that GLI3 normally represses Fgf8 independently of SHH
Saitsu et al., Dev Dyn 2005
:
In the previous genetic study, we showed that
Shh is
required for
Fgf15 expression in the diencephalon and midbrain ... These findings indicate that
Fgf15 is directly
regulated by
Shh signaling through Gli proteins
Esteve et al., Curr Opin Neurobiol 2006
:
In addition, later on in development,
Fgf controls the onset of retinal neurogenesis and
Shh and GDF11
control its feedback regulation
Naruse et al., Dev Biol 2006
:
However,
FGF-2 did not
induce dorsal expression of
Shh , Patched1 or Nkx2.1, and co-injection of FGF-2 and a Shh inhibitor did not attenuate the induction of Olig2 and PDGFRalpha, suggesting that Shh signaling was not involved in this FGF-2 mediated dorsal induction
Fogarty et al., Proc Natl Acad Sci U S A 2007
(Neoplasms) :
FGF also
inhibits transcription of
Shh target genes and prevents activation of a Gli-responsive promoter in fibroblasts, which suggests that it blocks Shh signaling upstream of Gli mediated transcription ...
FGF mediated inhibition of
Shh responses requires activation of FGF receptors and of ERK and JNK kinases, because it can be blocked by inhibitors of these enzymes
Hirashima et al., Bull Math Biol 2008
:
A recent experimental observation suggests that the
FGF-signal regulates the
Shh expression in a feed-forward manner with activation and repression regulatory pathways
Vinothkumar et al., Dev Biol 2008
:
Mutation of the binding sites or knockdown of Pea3 and Erm abolishes transgene expression, indicating that
Fgf signaling
regulates shh expression in the retina
Brito et al., Development 2008
:
In our experimental design, the extra source of
Shh activates
Fgf8 , Bmp4 and Shh genes in caudal BA1 ectoderm in a spatial pattern similar to that of the oral epithelium, and regularly leads to the formation of two extra lower-jaw organizing centers with opposite rostrocaudal polarities
Prykhozhij et al., BMC developmental biology 2008
:
The results presented here show that the role of
Shh in this process is indirect, and is
mediated by its effect on
Fgf signaling
Lee et al., Dev Biol 2009
:
Loss- and gain-of-function approaches indicate that
Fgf signaling
promotes shh expression in proximal epidermis, while Fgf/Ras signaling restricts shh expression from distal epidermis through induction of pea3 expression and maintenance of wnt5b
Mackem et al., Science signaling 2009
:
Fibroblast growth factor ( FGF ) signaling from the epithelium
regulates Sonic hedgehog (Shh) expression in the mesenchyme
Kobayashi et al., Dev Growth Differ 2010
:
Shh induces
Fgf8 expression in the ventral optic vesicle
Wang et al., Dev Biol 2010
:
Lastly, we show that
Shh/Gli2 signaling
controls the diencephalic expression of Bone morphogenetic protein 4 (Bmp4) and
Fibroblast growth factor 8 (Fgf8) , two genes that are known to play critical roles in patterning and growth of Rathke 's pouch
Mukhopadhyay et al., Dev Biol 2013
:
Here
FGF acutely
suppressed Shh transcription within 90min but had significantly less effect on Eda, WNT, Notch or BMP pathways ... Furthermore, in vivo Fgfr2 loss-of-function in the ectoderm caused derepression of Shh, revealing a
role for
FGF in
Shh regulation in the hair follicle
Grieshammer et al., Development 1996
:
These observations support the hypothesis that
Fgf8 is
required for the induction of
Shh expression during normal limb development
Logan et al., Development 1997
:
Consistent with recent evidence that there is a reciprocal interaction between signalling molecules in the dorsal ectoderm, AER, and zone of polarising activity ( ZPA ), loss of Wnt7a,
Fgf-8 and Fgf-4 expression
leads to a decrease in expression of the signalling molecule
Shh in the ZPA