Kim et al., J Cell Biol 2002
(Necrosis) :
Brain derived neurotrophic factor can act as a pronecrotic factor through transcriptional and translational activation of NADPH oxidase ... The present study suggests that BDNF induced expression and activation of NADPH oxidase cause oxidative neuronal necrosis and that the neurotrophic effects of NTs can be maximized under blockade of the pronecrotic action
Ejiri et al., Circulation 2005
(Angina Pectoris...) :
Stimulation with recombinant BDNF significantly enhanced NAD ( P ) H oxidase activity and the generation of reactive oxygen species in cultured human coronary artery smooth muscle cells