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APPL1 — RAB5A

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: RAB5A — APPL1 (physical association, affinity chromatography technology) Miaczynska et al., Cell 2004
• IRef Biogrid Interaction: RAB5A — APPL1 (direct interaction, pull down) Miaczynska et al., Cell 2004
• IRef Biogrid Interaction: RAB5A — APPL1 (physical association, affinity chromatography technology) Mao et al., Nat Cell Biol 2006*
• IRef Biogrid Interaction: RAB5A — APPL1 (direct interaction, pull down) Zhu et al., EMBO J 2007*
• IRef Hprd Interaction: RAB5A — APPL1 (in vivo) Miaczynska et al., Cell 2004
• IRef Hprd Interaction: RAB5A — APPL1 (in vitro) Miaczynska et al., Cell 2004
• IRef Intact Interaction: RAB5A — APPL1 (direct interaction, pull down) Zhu et al., EMBO J 2007*
• IRef Intact Interaction: RAB5A — APPL1 (direct interaction, surface plasmon resonance) Zhu et al., EMBO J 2007*
• IRef Intact Interaction: RAB5A — APPL1 (colocalization, fluorescence microscopy) Zhu et al., EMBO J 2007*

Text-mined interactions from Literome

Miaczynska et al., Cell 2004 : Both APPL1 and APPL2 are essential for cell proliferation and their function requires Rab5 binding
Chial et al., Traffic 2008 : Overexpression of full-length APPL-YFP fusion proteins was sufficient to recruit endogenous RAB5 to enlarged APPL associated membrane structures, although APPL1 was not necessary for RAB5 membrane targeting