Gene interactions and pathways from curated databases and text-mining

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IL2 — STAT1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Gollob et al., J Immunol 1999 : A specific inhibitor of p38 MAP kinase completely inhibits the serine phosphorylation of STAT1 and STAT3 induced by IL-12 and IL-2 and abrogates the functional synergy between IL-12 and IL-2 without affecting STAT tyrosine phosphorylation
Subramaniam et al., Biochem Biophys Res Commun 1999 : Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells, interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of JAK 1, 2 and 3, Tyk 2 and STAT 1 , 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
Lee et al., J Exp Med 1999 : Interestingly, interleukin (IL)-7 selectively activated STAT1 and induced MHC class I in mature T but not B cells
Owaki et al., J Immunol 2006 : Analyses using various mice lacking a signaling molecule revealed that the inhibition of IL-2 production was dependent on STAT1 , but not on STAT3, STAT4, and T-bet, and was highly correlated with the induction of SOCS3 expression
Tomic et al., J Immunol 2006 (Leukemia, Lymphocytic, Chronic, B-Cell...) : IL-2 with S28690 caused CLL cells to proliferate and increased their expression of B7-family members, production of TNF-alpha and IL-10, and levels of tyrosine phosphorylated STAT-1 and STAT-3 proteins
Beadling et al., EMBO J 1994 : IFN alpha activated STAT1 , STAT2 and STAT3 in T cells, but no detectable activation of these STATs was induced by IL-2
Yu et al., J Immunol 1996 : IL-2 induced less STAT1 alpha activation and IFN-alpha induced greater STAT5 activation in NK3.3 cells compared with preactivated primary NK cells
Wang et al., J Immunol 1999 : In both T cells and NK cells, IL-2 induces the activation of STAT1 , STAT3, and STAT5