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GNRH1 — IGF1

Text-mined interactions from Literome

Bourguignon et al., Brain Res 1999 : We showed previously that insulin-like growth factor-I (IGF-I) could inhibit the secretion of gonadotrophin releasing hormone (GnRH) evoked in vitro by N-methyl-D-aspartate ( NMDA ) or veratridine depolarization ... That effect was developmentally regulated since IGF-I could inhibit GnRH secretion from hypothalamic explants of 50-day-old adult rats but not from immature 15-day-old explants
Daftary et al., Endocrinology 2003 : To better understand the regulation of GnRH neurons by hypothalamic IGF-1, we quantified levels of IGF-1 mRNA in hypothalamic and preoptic regions containing GnRH cells, studied the effects of IGF-1 on GnRH gene expression, and examined the neuroanatomical relationship between GnRH neurons and hypothalamic IGF-1 in neonatal, peripubertal, and reproductively mature mice ... In contrast, IGF-1 had no effect or even inhibited GnRH gene expression in adult P60 mice
Dees et al., J Stud Alcohol 2005 : Furthermore, as alcohol ( ALC ) blocks IGF-1 induced LHRH and LH release acutely, we aimed to determine if it could affect the ability of IGF-1 to stimulate Oct 2 gene expression
Pine et al., Reprod Toxicol 2006 (Prenatal Exposure Delayed Effects...) : Because prepubertal female rats maternally exposed to lead ( Pb ) exhibit suppressed serum levels of insulin-like growth factor-1 (IGF-1) and delayed puberty, we investigated the ability of centrally administered IGF-1 to stimulate luteinizing hormone ( LH ) release in vivo and LH-releasing hormone (LHRH) release in vitro from maternally Pb-exposed prepubertal female rats ... These results indicate the central LHRH response to IGF-1 is intact and that Pb-induced delayed puberty is due , at least in part, to suppressed circulating IGF-1 available to the hypothalamus
Liu et al., Zhonghua Nan Ke Xue 2007 : IGF-1 can stimulate the expression of GnRH gene in the hypothalamus of prepubertal male mice
Hiney et al., Neuroendocrinology 1991 : The results demonstrate that IGF-I has the capability to act directly upon the median eminence to effect release of LHRH, thereby suggesting a role for IGF-I in facilitating peripubertal changes in LHRH release
Luckenbach et al., Gen Comp Endocrinol 2010 : Three experiments were conducted with dispersed pituitary cells of prepubertal male coho salmon ( Oncorhynchus kisutch ) to determine the time course of the response to IGF1, IGF1 concentration response , and GnRH concentration response
Hiney et al., Neuroscience 2010 : Since alcohol ( ALC ) blocks IGF-1 induced LHRH release acutely, we assessed whether this drug could affect IGF-1 stimulated prepubertal KiSS-1 gene expression following a binge type of exposure
Sun et al., Endocrinology 2011 : Differential effects of hypothalamic IGF-I on gonadotropin releasing hormone neuronal activation during steroid induced LH surges in young and middle aged female rats ... The present study investigated potential mechanisms by which IGF-I receptors in the neuroendocrine hypothalamus regulate GnRH neuronal activation and LH release in young and middle aged female rats under estradiol ( E2 ) positive feedback conditions ... These findings indicate that brain IGF-I receptors are required for E2 activation of GnRH neurons in young rats and for robust GnRH release from axon terminals in middle aged females
Kaneko et al., Diabetes 1985 (Body Weight...) : There were no differences in serum insulin-like growth factor I (IGF-I) levels between group 1 ( 262 +/- 35 ng/ml ) and group 2 ( 232 +/- 30 ng/ml ), and no significant correlation was found between serum IGF-I levels and GH responses to GRH in either of the two groups
Sato et al., Endocrinology 1993 (Dwarfism) : The roles of GH and insulin-like growth factor-I (IGF-I) in the regulation of hypothalamic GH-releasing hormone (GRH) and somatostatin ( SRIH ) gene expression were investigated in the GH-deficient dwarf ( dw ) rat, in which endogenous feedback signals are lacking
Bourguignon et al., Endocrinology 1994 : Growth Hormone Releasing Factor (GRF), Insulin-like Growth Factor-I (IGF-I) and Proinsulin result in inhibition of GnRH secretion ... Protease inhibitors prevent the inhibitory effects of IGF-I on GnRH secretion
Zhen et al., Mol Endocrinol 1997 : Regulation of gonadotropin releasing hormone (GnRH) gene expression by insulin-like growth factor I in a cultured GnRH expressing neuronal cell line ... A GnRH expressing neuronal cell line ( NLT ) was used to determine whether insulin-like growth factor I (IGF-I) regulates GnRH gene expression
Yamada et al., Endocr J 1997 (Acromegaly...) : Therefore, 34 ( 87.1 % ) out of 39 patients who have been followed up longer than 6 months met the following stringent criteria at the time of the final follow-up : mean basal GH level < 3 ng/ml, a normal IGF-1 level, and normal GH response to TRH, GnRH and oral glucose administration
Hiney et al., Life Sci 1998 : Thus, we have investigated the effects of ETOH on IGF-1 induced LH release in vivo, and on IGF-1 induced prostaglandin-E2 ( PGE2 ) and LH-releasing hormone (LHRH) release in vitro from rats during the juvenile phase of development as well as from rats during the early stage of first proestrus ... IGF-1 stimulated the release of PGE2 ( p < 0.001 ) and LHRH ( p < 0.01 ) from the incubated nerve terminals in the absence of ETOH ; however, these effects were blocked by the presence of ETOH
Longo et al., Endocrinology 1998 : We examined the effects of the neurotrophic factor insulin-like growth factor-I (IGF-I) on GnRH gene expression and the mechanism for these changes ... Initially, effects of IGF-I on GnRH gene expression were determined by ribonuclease protection assay ... The increase in GnRH mRNA levels induced by IGF-I is probably caused by a transcriptional mechanism, as evidenced by the increase in GnRH primary transcript levels before a change in GnRH mRNA levels, as well as our finding of a similar GnRH mRNA half-life for both control and IGF-I treated cells
Marelli et al., Endocrinology 1999 (Prostatic Neoplasms) : To this purpose, the effects of the LHRH agonist Zoladex (LHRH-A) on 1 ) the mitogenic action of IGF-I, 2 ) the tyrosine phosphorylation of type 1 IGF-I receptor (IGF-IR) , 3 ) the concentration of IGF-IR, and 4 ) the secretion of IGF binding protein-3 were studied