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IGF1 — NOS1

Text-mined interactions from Literome

Guan et al., Neuroscience 2000 (Brain Ischemia) : Insulin-like growth factor-1 markedly prevented the loss of calbindin-28kd ( n = 7, P < 0.05 ), choline acetyltransferase ( n = 7, P < 0.05 ), neuropeptide Y ( n = 7, P < 0.05 ), neuronal nitric oxide synthase ( n = 8, P < 0.05 ) and glutamate acid decarboxylase ( n = 9, P < 0.05 ) immunopositive neurons, but failed to protect parvalbumin ( n = 6 ) immunopositive neurons
Castrillo et al., Diabetes 2000 : Inhibitory effect of IGF-I on type 2 nitric oxide synthase expression in Ins-1 cells and protection against activation dependent apoptosis : involvement of phosphatidylinositol 3-kinase
Isenovic et al., Endocrine 2002 : Pretreatment with Ang II for 5 min reduced IGF-1 induced NOS activity
Isenovic et al., Metabolism 2003 : Interactive effects of insulin-like growth factor-1 and beta-estradiol on endothelial nitric oxide synthase activity in rat aortic endothelial cells
Esberg et al., Comp Biochem Physiol A Mol Integr Physiol 2004 (Body Weight) : IGF-1 ( 10 ( -10 ) -10 ( -6 ) m ) induced a concentration dependent inhibition of NOS activity in male myocytes with a maximal inhibition of 22.2 %
Thum et al., Circ Res 2007 : IGF-1 increased telomerase activity, endothelial nitric oxide synthase expression, phosphorylation and activity in EPC in a phosphoinositide-3-kinase/Akt dependent manner
Ma et al., Biochem Biophys Res Commun 2009 : However, IGF-1 enhanced NOS activity, NO content, and the expression level of cyclin E protein, and reduced the expression level of AT(1) mRNA
Stone et al., J Gerontol A Biol Sci Med Sci 2012 : Moreover, IGF-1 also activated endothelial nitric oxide synthase in human umbilical vein endothelial cells