Gene interactions and pathways from curated databases and text-mining

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HSPG2 — RELA

Text-mined interactions from Literome

Satoh et al., Am J Physiol Gastrointest Liver Physiol 2004 : Activation of PKC-delta, PKC-epsilon, and NF-kappaB with CCK-8 involved both phosphatidylinositol-specific PLC and phosphatidylcholine ( PC ) -specific PLC, whereas with TNF-alpha they only required PC-specific PLC for activation
Mentaverri et al., FASEB J 2006 : Similar to RANKL, Ca ( o ) 2+ ( 20 mM ) appeared to trigger rapid and significant nuclear translocation of NF-kappaB in a CaR- and PLC dependent manner
Ndisang et al., J Card Fail 2009 (Hypertension...) : Aldosterone and phospholipase C (PLC) stimulate nuclear factor-kappaB (NF-kappaB) and activating-protein ( AP-1 ), causing fibrosis and hypertrophy
Tzeng et al., Pharmacol Res 2010 : In this study, we examined the role of phosphatidylcholine-phospholipase C ( PC-PLC ) and protein kinase C ( PKC ) in peptidoglycan ( PGN ) -induced nuclear factor-kappaB (NF-kappaB) activation and cyclooxygenase-2 (COX-2) expression in RAW 264.7 macrophages
Spadaro et al., PloS one 2013 : Finally, PI-PLC inhibition neither blocks gp120 mediated NF-kB activation nor overall accumulation of CCL2 mRNA, whereas it decreases CCL2 transcript level in the cytoplasm
Arenzana-Seisdedos et al., J Virol 1993 : Induction of NF-kappa B by PC-PLC did not depend on de novo synthesis of proteins or autocrine secretion of either tumor necrosis factor or interleukin 1 ... In human monocytic and lymphoblastoid T-cell lines, induction of NF-kappa B by PC-PLC resulted in clear induction of luciferase expression vectors placed under the control of synthetic kappa B enhancers or wild type, but not kappa B-mutated, HIV long terminal repeat constructs ... PC-PLC induced NF-kappa B activation could not be blocked by a specific inhibitor of phorbol ester-inducible protein kinases C
Dominguez et al., Mol Cell Biol 1993 : In this report, we present evidence that in oocytes from Xenopus laevis, ( i ) ras p21- and phospholipase C (PLC) mediated phosphatidylcholine ( PC ) hydrolysis activates NF-kappa B and ( ii ) protein kinase C zeta subspecies is involved in the activation of NF-kappa B in response to insulin/ras p21/PC-PLC
Carter et al., Am J Respir Cell Mol Biol 1998 (Respiratory Distress Syndrome, Adult) : Lipopolysaccharide induced NF-kappaB activation and cytokine release in human alveolar macrophages is PKC independent and TK- and PC-PLC dependent