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GRP — INS

Text-mined interactions from Literome

Persson et al., Am J Physiol Endocrinol Metab 2000 (Glucose Intolerance) : In conclusion, this study has shown that 1 ) plasma levels of intact GLP-1 increase dose dependently on gastric glucose challenge in correlation with increased insulin levels in mice, and 2 ) intact GRP receptors are required for normal GLP-1 and insulin responses and glucose tolerance after gastric glucose in mice
Peyrollier et al., Biochem J 2000 : Disassembly of the actin cytoskeleton significantly reduced the insulin mediated translocation of both PKB-PH-GFP and GRP1-PH-GFP to the plasma membrane, consistent with diminished synthesis of 3-phosphoinositides
Persson et al., Endocrinology 2002 (Insulin Resistance) : To explore whether islet GRP contributes to neurally mediated insulin secretion, we studied GRP receptor (GRPR) deleted mice ... This shows that GRPR is the receptor subtype mediating GRP induced insulin secretion and that GRPR deleted mice are tools for studying the physiological role of islet GRP
Houghton et al., Endocrinology 1992 : E2 alone did not alter the insulin response to GRP compared to control, but E2 plus P4 treatment attenuated these responses to values similar to those in pregnant animals
Ahrén et al., Endocrinology 2005 : The augmented insulin response to GRP by val-pyr was prevented by the GLP-1 receptor antagonist, exendin ( 3 ) ( 9-39 ), raising the possibility that GRP effects may occur secondary to stimulation of GLP-1 secretion
Ahrén et al., Nutr Metab Cardiovasc Dis 2006 : This study examined whether the neuropeptides, pituitary adenylate cyclase activating polypeptide ( PACAP ) and gastrin releasing polypeptide (GRP) contribute to the regulation of insulin secretion in model experiments by using receptor gene deleted mice
Mukai et al., Peptides 1990 : The antagonistic effects of [ D-Phe25 ] gastrin releasing peptide (GRP) ( 18-27 ) and [ D-Arg1, D-Pro2,D-Trp7,9,Leu11 ] substance P ( SP ) on the stimulation of insulin release by GRP ( 18-27 ) from isolated canine pancreas were compared with that of [ Ala23 ] GRP ( 18-27 ) ... The stimulation of insulin release by 1 nM GRP ( 18-27 ) was reduced to 24.1 % and 15.4 % by the prior infusion of 1 microM of [ D-Arg1, D-Pro2,D-Trp7,9,Leu11 ] SP and 10 microM of [ D-Phe25 ] GRP ( 18-27 ), respectively
Ko et al., Biosci Biotechnol Biochem 2007 (Diabetes Mellitus) : In partial pancreatectomized ( Px ) diabetic mice, both GR and GRP improved glucose tolerance, but only GRP enhanced glucose stimulated insulin secretion as much as exendin-4
Hermansen et al., Acta Physiol Scand 1990 : We found that, at all four concentrations tested, GRP rapidly and markedly stimulated insulin secretion ... We conclude that GRP stimulates insulin secretion by a direct pancreatic action without affecting the secretion of glucagon or somatostatin
Wahl et al., Endocrinology 1991 : In the presence of a stimulatory glucose concentration, GRP augmented insulin secretion of isolated islets in batch incubations ... It is suggested that GRP plays a role in the regulation of glucose induced insulin secretion by increasing the uptake of Ca2+ directly or by inhibition of the Ca ( 2+ ) -dependent K+ channel activity and reduced repolarization of the cell
Kawai et al., Endocrinol Jpn 1990 (Zollinger-Ellison Syndrome) : Effects of neuromedin B and GRP-10 on gastrin and insulin release from cultured tumor cells of a malignant gastrinoma ... However, insulin release from cultured cells of the pancreatic tumor was stimulated by GRP-10 , but not by neuromedin B
Schnuerer et al., Regul Pept 1987 : The present study was designed to determine the effects of intravenously administered galanin or gastrin releasing peptide (GRP) on glucose- and/or glucose dependent insulinotropic peptide ( GIP ) -stimulated insulin release in the anaesthetized rat ... GRP inhibited glucose stimulated insulin responses, and the insulin responses to glucose plus GIP ; unlike galanin, GRP inhibited both glucose- and GIP stimulated insulin release ... GRP also inhibited insulin release following ingestion of a mixed meal
Mukai et al., Am J Physiol 1989 : Because the stimulation of insulin and gastrin secretion by GRP-10 has been ascribed to a direct effect on B- and G-cells, these findings suggest that there are two subtypes of receptors for bombesin-like peptides in mammalian tissues
Kawai et al., Endocrinol Jpn 1989 : The effect of C-terminal decapeptide of gastrin releasing peptide ( GRP-10 ) was also examined and similar results were obtained ; 10 nM and 100 nM GRP-10 did not affect insulin release and 100 nM GRP-10 stimulated glucagon release under the perfusate condition of 5.5 mM glucose plus 10 mM arginine
Knuhtsen et al., Regul Pept 1987 : GRP- ( 1-27 ) stimulated insulin and pancreatic polypeptide secretion and inhibited somatostatin secretion in a dose dependent manner ... The effect of GRP- ( 1-27 ) on insulin secretion was enhanced with increasing perfusate glucose levels, whereas the effects upon somatostatin and pancreatic polypeptide secretion were independent of perfusate glucose levels
Kasambalides et al., J Cell Physiol 1985 : We now show that insulin , even in the presence of high extracellular glucose concentrations, will induce 95K and 82K GRP synthesis while suppressing 85K and 69K HSP synthesis
Pettersson et al., Neuropeptides 1988 : Furthermore, GRP ( 1.1 or 4.3 pmol/min ) potentiated the plasma insulin response to glucose ( 7 mg/min )
Kawai et al., Acta Endocrinol (Copenh) 1988 : Both NMB and GRP-10 ( 0.1-100 nmol/l ) stimulated insulin release from the isolated canine pancreas
Greeley et al., Proc Soc Exp Biol Med 1986 : Effect of bombesin and gastrin releasing peptide on the release of gastric inhibitory polypeptide and insulin in rats ... The objective of this study was to determine whether bombesin- or gastrin releasing peptide induced release of insulin occurs before or after the release of gastric inhibitory polypeptide (GIP) in rats
Pettersson et al., Peptides 1987 : In this study, we investigated the effects of GRP on basal and stimulated insulin and glucagon secretion in the mouse ... Moreover, methylatropine given at a dose level that totally abolishes carbachol induced insulin secretion inhibited GRP induced insulin secretion by 39 % ( p less than 0.05 ) and GRP induced glucagon secretion by 25 % ( p less than 0.01 ) ... L-Propranolol at a dose level that totally abolishes beta-adrenergically induced insulin secretion inhibited GRP induced insulin secretion by 52 % ( p less than 0.01 ) and GRP induced glucagon secretion by 15 % ( p less than 0.05 ) ... In summary, we have shown that GRP stimulates basal and potentiates stimulated insulin and glucagon secretion in mice, and that the stimulatory effects of GRP on insulin and glucagon secretion are partially inhibited by muscarinic blockade by methylatropine or by beta-adrenoceptor blockade by propranolol ... We conclude that GRP activates potently both insulin and glucagon secretion in the mouse by mechanisms that are partially related to the muscarinic and the beta-adrenergic receptors
Figlewicz et al., Am J Physiol 1985 : GRP at doses of 1, 2, 4, and 8 micrograms/kg stimulated basal insulin secretion
Bloom et al., J Physiol 1984 : Pre-treatment with amino acids alone substantially and significantly increased the rise in mean plasma insulin that occurred in response to GRP
Knigge et al., J Clin Endocrinol Metab 1984 : GRP stimulated the secretion of gastrin, pancreatic polypeptide, insulin , glucagon, and glucose dependent insulinotropic polypeptide in a dose dependent manner
Gregersen et al., Pancreas 1996 : In contrast to GRP induced insulin secretion, the GRP induced 86Rb+ efflux was sustained throughout the stimulation period, suggesting that increased K+ conductance may be involved in the vanishing effect of GRP on insulin secretion ... Furthermore, both inhibition of protein kinase C ( PKC ) by staurosporine ( 1-10 microM ) and down-regulation of PKC activity by long-term incubation with the phorbol ester 12-O-tetradecanoyl phorbol-13-acetate inhibited GRP stimulated insulin secretion ( p < 0.05 ) ... In contrast, GRP stimulated insulin secretion was abolished by an inhibitor of phospholipase D, wortmannin ( 1 microM )
Karlsson et al., Am J Physiol 1998 : Furthermore, afferent denervation by neonatal capsaicin did not affect the insulin response to GRP