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INS — PIKFYVE

Text-mined interactions from Literome

Sbrissa et al., Mol Cell Endocrinol 2001 : Insulin but not PDGF or EGF stimulation of 3T3-L1 adipocytes markedly increased the PtdIns 3-P production ( 4.2-fold ) in PIKfyve immune complexes, primarily as a result of increased PI 3-K intrinsic enzymatic activity
Berwick et al., J Cell Sci 2004 : We also demonstrate that PIKfyve is phosphorylated on serine318 in intact cells in response to insulin , in a PI3-kinase dependent manner, and that PIKfyve colocalises with a highly motile subpopulation of insulin regulated aminopeptidase (IRAP)/GLUT4 vesicles
Hill et al., Biochem Biophys Res Commun 2010 : Regulation of PIKfyve phosphorylation by insulin and osmotic stress ... We have previously demonstrated that PIKfyve is phosphorylated in response to insulin in a PI3-kinase and protein kinase B (PKB) dependent manner ... Our results confirm, therefore, that PIKfyve is directly phosphorylated by PKB on a single serine residue in response to insulin and are not due to autophosphorylation of the enzyme