Suryawan et al., Am J Physiol Endocrinol Metab 2007
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INS , but not AA, increased the phosphorylation of protein kinase B (PKB) and tuberous sclerosis 2 (TSC2) Zhang et al., Free Radic Biol Med 2009
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Insulin signaling to mTORC1 is dependent upon phosphorylation of Akt/PKB and the inhibition of the tuberous sclerosis complex ( TSC1/2 ), thereby enhancing the phosphorylation of 4E-BP1 and S6K1 ... We show that insulin stimulated the phosphorylation of TSC2 leading to a reduction in raptor-mTOR binding and in the quantity of proline-rich Akt substrate 40 ( PRAS40 ) precipitating with mTOR
Bartolomé et al., Endocrinology 2010
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Thus, we propose that the regulation of TSC2 phosphorylation by insulin or glucose independently integrates beta-cell proliferation signaling, the relative expression of IRA or IRB isoforms in pancreatic beta cells playing a major role
Koyanagi et al., PloS one 2011
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Activation of mTORC1 by TSC2 ablation increases mitochondrial biogenesis and enhances insulin secretion from pancreatic beta cells