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EGF — FST

Text-mined interactions from Literome

Michel et al., J Mol Endocrinol 1992 : Activin raised basal as well as FSH stimulated steady-state follistatin mRNA levels up to ten- and twofold above controls respectively, whereas epidermal growth factor was found to inhibit FSH stimulated follistatin mRNA levels in a dose dependent manner ... It is concluded that follistatin mRNA levels in granulosa cells are regulated by FSH rather than LH, and that the stimulation by FSH can be inhibited by epidermal growth factor but enhanced by activin
Bearfield et al., Eur J Endocrinol 2005 : Secretion of inhibin A, activin A and follistatin in the presence of EGF , IL-1beta, activin A and follistatin were measured using in-house ELISAs
Lindsell et al., Endocrine 1995 : Results in the longer term differed, as pretreatment of granulosa cells with CHX for 20 h suppressed the induction of follistatin gene expression by both EGF and phorbol 12-myristate-13-acetate
Lindsell et al., Endocrinology 1993 : EGF ( 0.01, 0.1, 1, and 10 nM ) induced a dose dependent induction of follistatin gene expression in granulosa cells after 2-h incubation, with maximal stimulation of 33-fold at a dose of 1 nM ... Pretreatment of granulosa cells for 24 h with PMA abrogated the EGF induced stimulation of follistatin mRNA accumulation ... These results demonstrate that 1 ) follistatin gene expression in cultured porcine granulosa cells is acutely stimulated by PMA and EGF in a time- and dose dependent manner ; 2 ) follistatin gene expression may be regulated by the PKC pathway ; and 3 ) the stimulatory effect of EGF on follistatin gene expression may require PKC
Zhang et al., Hepatology 1996 : EGF augmented the release of follistatin , an activin binding protein known to block the action of activin A, by hepatocytes and NE did not affect the amount of follistatin they released