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MAPK12 — PTK2B
Text-mined interactions from Literome
Pandey et al., J Biol Chem 1999
:
Overexpression of
RAFTK leads to the activation of p38
MAPK ... We observe that the dominant negative mutant of MKK3 but not of MKK6, SEK1, or MEK1 inhibits
RAFTK induced p38
MAPK activity
Kumar et al., J Biol Chem 1999
:
Overexpression of
RAFTK induces activation of c-Jun amino-terminal kinase ( also known as stress activated protein kinase ),
mitogen activated protein kinase ( MAPK ), and p38 MAPK ... Furthermore, in contrast to the phosphatase-dead SHPTP1 C453S mutant, overexpression of wild-type SHPTP1 blocks interaction of RAFTK with the SH2-domain of c-Src and inhibits
RAFTK mediated
MAPK activation
Hatch et al., Blood 1998
(Leukemia, Monocytic, Acute) :
Inhibition of
RAFTK by a dominant negative kinase mutant
reduced CSF-1/M-CSF induced
MAPK activity