◀ Back to NFKB1
CXCL10 — NFKB1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Borgland et al., J Virol 2000
:
Coinfection of REC cells with adCMVbetagal and an adenoviral vector expressing IkappaBalpha resulted in suppression of adCMVbetagal induced expression of IP-10 at 6 and 16 h, further strengthening the conclusion that adenovirus induced activation of
IP-10 is
dependent on
NF-kappaB ... Together, these findings demonstrate that adenovirus vectors directly
induce the expression of
IP-10 through capsid dependent activation of
NF-kappaB
Méndez-Samperio et al., J Interferon Cytokine Res 2002
:
Finally, two specific
NF-kappa B inhibitors, sulfasalazine and caffeic acid phenetyl ester ( CAPE ), strongly
inhibited the production of
CXCL-8 by human monocytes infected with M. bovis
Hiroi et al., Biochem J 2003
(Carcinoma...) :
Activation of
NF-kappaB in Ca9-22 cells
restored the expression of IFNgamma stimulated CXCL9 and
CXCL10 mRNAs ... In contrast, inhibition of the constitutive
NF-kappaB in HSC-2 cells by adenovirus mediated gene transfer of a dominant negative IkappaBalpha
suppressed the IFNgamma induced expression of the CXCL9 and
CXCL10 mRNAs ... These results indicate that constitutive
NF-kappaB activity, which is often associated with tumour development, is
required for the induced expression of CXCL9 and
CXCL10 genes in human tumour cell lines in response to IFNgamma
Hardaker et al., FASEB J 2004
(Inflammation...) :
TNF-alpha induced
CXCL10 expression in hASM was
dependent on
NFkappaB activation, and a salicylanilide NFkappaB inhibitor blocked the CXCL10 expression
Chandrasekar et al., J Biol Chem 2004
(Arteriosclerosis...) :
In conclusion,
CXCL16 is a potent and direct
activator of
NF-kappaB and induces kappa B-dependent proinflammatory gene transcription
Si et al., J Immunol 2004
(Acquired Immunodeficiency Syndrome) :
Adenoviral transduction of super-repressor IkappaBalpha, dominant negative MKK6, and dominant negative Ras demonstrated that
NF-kappaB and p38 MAPK were
involved in LPS induced IFN-inducible protein
10/CXCL10 production ... Interestingly, although LPS induced
IL-8/CXCL8 was
dependent on
NF-kappaB , the baseline or 15d-PGJ ( 2 ) -mediated IL-8/CXCL8 production was NF-kappaB independent
Cinatl et al., Int J Mol Med 2005
(Colonic Neoplasms...) :
High hydrocortisone concentrations ( > or =50 microg/ml ) completely prevented increased DNA binding activity of AP-1 and
NF-kappaB and
inhibited up-regulation of CXCL8 and
CXCL10 , but did not reduce chemokine expression to basal levels ... High hydrocortisone concentrations ( > or =50 microg/ml ) completely prevented increased DNA binding activity of AP-1 and
NF-kappaB and
inhibited up-regulation of
CXCL8 and CXCL10, but did not reduce chemokine expression to basal levels
Keshamouni et al., Neoplasia (New York, N.Y.) 2005
(Carcinoma, Non-Small-Cell Lung...) :
Similarly, an inhibitor of
NF-kappa B activation ( PDTC ) also
blocked CXCL8 , CXCL5, and CXCL1 production, consistent with their NF-kappa B-dependent regulation
Zhang et al., Mol Cell Biol 2005
:
In the characterization of the IP10 induced apoptotic pathway, we found that overexpression of
IP10 upregulated p53 and
resulted in altered expression of p53-responsive genes such as the p21Cip1, p27kip1,
NF-kappaB , Bax, and PUMA genes and the mitochondrial translocation of Bax
Nakamichi et al., J Neurochem 2005
:
Taken together, these results suggest that the recognition of dsRNA structure selectively
induces the
CXCL10 and CCL5 responses in microglia through vacuolar pH-dependent activation of
NF-kappaB and MAPK signaling pathways
Liu et al., J Virol 2005
:
Akt/protein kinase B activation by adenovirus vectors contributes to
NFkappaB dependent
CXCL10 expression
Wong et al., Allergy 2006
:
Using various selective inhibitors for signaling molecules, we found that the inductions of IL-8, MCP-1, and I-309 were mediated by either SCF activated ERK or TNF-alpha activated p38 MAPK, while the induction of
IP-10 by TNF-alpha was
mediated by both activated p38 MAPK and
NF-kappaB
Law et al., J Virol 2007
:
Our results showed that the SARS coronavirus nsp-1
plays an important role in CCL5,
CXCL10 , and CCL3 expression in human lung epithelial cells via the activation of
NF-kappaB
Liu et al., J Virol 2007
:
In contrast, siRNA mediated TLR3 knockdown did not affect RSV induced
NF-kappaB binding but did
inhibit IFN-beta,
IP-10 , CCL-5, and ISG15 expression at late times of infection
Laine et al., Biochem Biophys Res Commun 2007
:
PA also induced an approximately 2-fold increase ( p < 0.05 ) in active NF-kappaB, and two structurally distinct
NF-kappaB inhibitors effectively
blocked PA-induced
IP-10 gene expression ... These results suggest that elevated concentrations of PA commonly present in obese and insulin resistant individuals can increase
NF-kappaB mediated expression of
IP-10 in macrophages
D'Aversa et al., J Neurosci Res 2008
(AIDS Dementia Complex...) :
Gel shift analyses demonstrated that
NFkappaB and AP-1, but not C/EBPbeta,
mediate microglial
CXCL8 production
Yang et al., Mol Immunol 2008
(Escherichia coli Infections...) :
Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate
NF-kappaB in mammary epithelial cells and to quickly
induce TNFalpha and interleukin-8 (
CXCL8 ) expression in the udder
Yeruva et al., Int J Colorectal Dis 2008
(Adenocarcinoma...) :
NF-kappaB dependent synergistic regulation of
CXCL10 gene expression by IL-1beta and IFN-gamma in human intestinal epithelial cell lines ... Real-time PCR and ELISA experiments using a specific NF-kappaB inhibitor and transfection experiments with a NF-kappaB binding defective CXCL10 promoter construct revealed that the induction of
CXCL10 by IL-1beta and its synergism with IFN-gamma is
NF-kappaB dependent
Bischoff et al., J Cell Biochem 2008
:
NF-kappaB inhibition
resulted in a decrease in
CXCL8 levels in hMSCs grown in non-OGM
Yin et al., Pediatr Transplant 2008
(Vascular Diseases) :
Both LFO and HFO significantly decreased the CAV score, inhibited recruitment of T lymphocytes and macrophages, elevated the activity of PPAR gamma,
inhibited the activity of
NF-kappaB , reduced levels of intragraft MCP-1 and
IP-10 as well as downregulated expression of chemokine receptors CCR2
Martin et al., J Biol Chem 2009
:
Furthermore, we identified the components of the CBM complex, Carma3, Bcl10, and Malt1, as key mediators of the
CXCL8/IL8 induced
NFkappaB activation and VEGF up-regulation
Qi et al., J Cell Physiol 2009
:
JAKs inhibitors suppressed IFN-gamma plus TNF-alpha induced production of CXCL10 in parallel with activation of STAT1 and NF-kappaB, while ERK inhibitor suppressed production of
CXCL10 as well as
activation of
NF-kappaB , but not that of STAT1
Koetzler et al., J Allergy Clin Immunol 2009
(Picornaviridae Infections) :
To define the molecular mechanisms by which NO
inhibits HRV-16 induced epithelial production of
CXCL10 by affecting nuclear translocation and binding of
nuclear factor-kappaB (NF-kappaB) and IFN regulatory factor 1 (IRF-1)
Ho et al., J Immunol 2009
:
In contrast, NE did not induce NRF expression in A549 and Beas-2B cells, where NE only stimulates
NF-kappaB activation and
IL-8/CXCL8 induction
Williams et al., Glia 2010
:
Additionally, apocynin was also able to reduce Tat and cytokine mediated activation of the corresponding signaling molecules Erk1/2, Jnk, and Akt with a decrease in activation and nuclear translocation of
NF-kappaB , important
regulators of
CXCL10 induction
Zhou et al., J Biol Chem 2010
(Hepatitis B, Chronic) :
As a consequence, up-regulation of
IP-10 may mediate the migration of peripheral blood leukocytes in a
NF-kappaB dependent manner
Khalaf et al., BMC immunology 2010
(Inflammation) :
The present study shows that
NF-kappaB regulated IL-6 but not
CXCL8