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FOS — MMP13
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Westermarck et al., FASEB J 1999
(Neoplasm Invasiveness...) :
This review will summarize the current view on the role of MMPs in tumor growth, invasion, and survival, and focus on the
role of mitogen activated protein kinases and
AP-1 and ETS transcription factors in the regulation of
MMP gene expression during invasion process
Onodera et al., J Biol Chem 2002
:
Similarly, a selective mitogen activated protein kinase ( MAPK ) kinase ( MEK)1/2 inhibitor ( PD98059 ) and
c-jun/activator protein (AP)-1 inhibitor ( curcumin )
suppressed MMP-13 mRNA up-regulation induced by MIF
Liacini et al., Exp Cell Res 2003
:
Induction of
matrix metalloproteinase-13 gene expression by TNF-alpha is
mediated by MAP kinases,
AP-1 , and NF-kappaB transcription factors in articular chondrocytes
Zeliadt et al., Biochem Biophys Res Commun 2004
:
MMP-13 promoter studies indicated that TPA
requires AP-1 , but not Runx, to induce
MMP-13 gene expression
Kajanne et al., J Cell Physiol 2007
:
Here we provide genetic and biochemical evidence that EGF-R- and
AP-1 mediated signals are
required for
MMP expression and collagen contraction in fibroblasts
Oliver et al., J Rheumatol 2007
(Arthritis, Experimental...) :
We evaluated whether a vanadium
AP-1 inhibitor could
reduce MMP expression and subsequent joint damage in CIA
Lu et al., J Cell Physiol 2009
:
These results suggest that hypoxia induced
MMP-13 expression in astrocytes is
regulated by
c-Fos and c-Jun
Hasegawa et al., Exp Cell Res 2009
(Neoplasm Invasiveness) :
To assess the role of AP-1 function, we examined the
effects of dominant negative
Fos ( DeltaFos ), BATF and siRNA against c-Jun on
MMP production in v-Crk transformed cells which have augmented production of MMP-2 and MMP-9