Richard et al., J Biol Chem 1999
(Anoxia) :
p42/p44 mitogen activated protein kinases phosphorylate hypoxia-inducible factor 1alpha ( HIF-1alpha ) and enhance the transcriptional activity of HIF-1 Fradette et al., Curr Drug Metab 2004
(Anoxia...) :
The up-regulation of CYP3A6 implies a PTK- and p42/44MAPK dependent stabilization/activation, nuclear translocation of HIF-1 and AP-1, binding to CYP3A6 promoter, and transactivation of the gene to induce CYP3A6 expression
Li et al., Clin Cancer Res 2004
(Anoxia...) :
Additional analyses using LY294002 and U0126 indicated that the increase in hypoxia-inducible factor 1 (HIF-1)alpha protein level was highly dependent on phosphatidylinositol 3'-kinase and p42/p44 mitogen activated protein kinase activities in hypoxic MDA-MB-468 cells