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PTX3 — SRC

Text-mined interactions from Literome

Khare et al., Am J Physiol 1999 : PTx , moreover, inhibited the stimulation of pp60(c-src) and PKC-alpha by 1,25 ( OH ) 2D3
Gao et al., J Pharmacol Exp Ther 2001 : In this study, activation of the Gq/G11 coupled thromboxane A2 (TxA2) receptor ( TP ) by the TxA2 mimetic IBOP in ECV304 cells was found to induce extracellular regulated kinase (ERK) phosphorylation and tyrosine phosphorylation of the epidermal growth factor receptor (EGFR), which were inhibited by the TP antagonist SQ29548, the EGFR kinase inhibitor AG1478, the Src family kinase inhibitor PP1, the Gi/o protein inhibitor pertussis toxin ( PTX ), or the protein kinase C ( PKC ) inhibitor calphostin C. TP activation also increased Src kinase activity, which was blocked by PTX , PP1, and calphostin C, but not by AG1478, indicating that Src activation occurs before phosphorylation of EGFR
Xu et al., Cell Adh Migr 2007 : Interestingly, P-selectin did not induce a detectable interleukine-8 (IL-8) secretion ( < 0.1 ng/ml ) in 30 minutes, whereas a high concentration of IL-8 ( > 50 ng/ml ) was required to increase neutrophil adhesion to Fg. P-selectin induced neutrophil adhesion was significantly inhibited by PP2 ( a Src kinase inhibitor ), but not by pertussis toxin ( PTX ; a GPCR inhibitor )
Conway et al., Biochem J 1999 : Furthermore, the PTX dependent decrease in c-Src and p42/p44 MAPK activation appeared correlated